5F-ADB (also known asMDMB-5F-PINACA using systematicEMCDDA nomenclature[2] and5F-MDMB-PINACA) is anindazole-based syntheticcannabinoid from the indazole-3-carboxamide family, which has been used as an active ingredient insynthetic cannabis products and has been sold online as adesigner drug.[3][4] 5F-ADB is a potentagonist of theCB1 receptor,[5] though it is unclear whether it is selective for this target.
5F-ADB was first identified in November 2014 frompost-mortem samples taken from an individual who had died after using a product containing this substance. Subsequent testing identified 5F-ADB to have been present in a total of ten people who had died from unexplained drug overdoses in Japan between September 2014 and December 2014. 5F-ADB is believed to be extremely potent based on the very low levels detected in tissue samples, and appears to be significantly more toxic than earlier synthetic cannabinoid drugs that had previously been sold.[6]
In 2018, 5F-ADB was the most common synthetic cannabinoid to be identified inDrug Enforcement Administration seizures.[7] 5F-ADB was also identified incannabidiol (CBD) products from a US-based CBD manufacturer in 2018.[8]
The positional isomer,4F-MDMB-PINACA has been characterised and is sometimes known as 4F-ADB,[11] despite "ADB" not having been used as a name forMDMB-PINACA. This is distinct from4F-MDMB-BINACA which is a notable compound in its own right.
^Shevyrin V, Melkozerov V, Nevero A, Eltsov O, Shafran Y, Morzherin Y, et al. (August 2015). "Identification and analytical characteristics of synthetic cannabinoids with an indazole-3-carboxamide structure bearing a N-1-methoxycarbonylalkyl group".Analytical and Bioanalytical Chemistry.407 (21):6301–6315.doi:10.1007/s00216-015-8612-7.PMID25893797.S2CID31838655.
^Banister SD, Longworth M, Kevin R, Sachdev S, Santiago M, Stuart J, et al. (September 2016). "Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues".ACS Chemical Neuroscience.7 (9):1241–1254.doi:10.1021/acschemneuro.6b00137.PMID27421060.
^asegawa K, Wurita A, Minakata K, Gonmori K, Yamagishi I, Nozawa H, et al. (2014). "Identification and quantitation of 5-fluoro-ADB, one of the most dangerous synthetic cannabinoids, in the stomach contents and solid tissues of a human cadaver and in some herbal products".Forensic Toxicology.33:112–121.doi:10.1007/s11419-014-0259-0.S2CID45508189.
