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| ECHA InfoCard | 100.257.468 |
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| Formula | C20H28FN3O3 |
| Molar mass | 377.460 g·mol−1 |
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5F-ADB (also known asMDMB-5F-PINACA using systematicEMCDDA nomenclature[2] and5F-MDMB-PINACA) is anindazole-based syntheticcannabinoid from the indazole-3-carboxamide family, which has been used as an active ingredient insynthetic cannabis products and has been sold online as adesigner drug.[3][4] 5F-ADB is a potentagonist of theCB1 receptor,[5] though it is unclear whether it is selective for this target.
5F-ADB was first identified in November 2014 frompost-mortem samples taken from an individual who had died after using a product containing this substance. Subsequent testing identified 5F-ADB to have been present in a total of ten people who had died from unexplained drug overdoses in Japan between September 2014 and December 2014. 5F-ADB is believed to be extremely potent based on the very low levels detected in tissue samples, and appears to be significantly more toxic than earlier synthetic cannabinoid drugs that had previously been sold.[6]
In 2018, 5F-ADB was the most common synthetic cannabinoid to be identified inDrug Enforcement Administration seizures.[7] 5F-ADB was also identified incannabidiol (CBD) products from a US-based CBD manufacturer in 2018.[8]
5F-MDMB-PINACA has been associated with 25 deaths in Europe between 2015 and 2017.[9]
In the United States, 5F-ADB is aschedule I controlled substance.[10]
5F-ADB was added to the Japanese banned drug list in December 2014.
The positional isomer,4F-MDMB-PINACA has been characterised and is sometimes known as 4F-ADB,[11] despite "ADB" not having been used as a name forMDMB-PINACA. This is distinct from4F-MDMB-BINACA which is a notable compound in its own right.