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| Clinical data | |
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| Other names | 5-Methylthio-N,N-dimethyltryptamine; 5-Methylthio-DMT |
| Routes of administration | Smoking[1] |
| Drug class | Serotonergic psychedelic;Hallucinogen |
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| Pharmacokinetic data | |
| Onset of action | Very fast[1] |
| Duration of action | 10–30 minutes or <1 hour[1] |
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| Chemical and physical data | |
| Formula | C13H18N2S |
| Molar mass | 234.36 g·mol−1 |
| 3D model (JSmol) | |
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5-MeS-DMT, also known as5-methylthio-N,N-dimethyltryptamine or as5-methylthio-DMT, is a lesser-knownpsychedelic drug of thetryptamine family.[1] It is the 5-methylthioderivative ofdimethyltryptamine (DMT) and is ananalogue of5-MeO-DMT.[1]
In his bookTiHKAL (Tryptamines I Have Known and Loved),Alexander Shulgin lists the dose as 15 to 30 mgsmoked and itsduration as less than 1 hour.[1] In individual reports, the duration was 10 to 30 minutes.[1] The effects included feelingstoned and novisuals, among others.[1] It was also described as coming on very fast and being quite intense.[1] The drug is described as being about half aspotent as 5-MeO-DMT.[1]
5-MeS-DMT was less potent than 5-MeO-DMT andpsilocin (4-HO-DMT) but more potent than4-MeO-DMT or4-MeS-DMT in rodent behavioral studies.[2][3][4]
Thechemical synthesis of 5-MeS-DMT has been described.[1]
Analogues of 5-MeS-DMT includedimethyltryptamine (DMT),5-MeO-DMT, and5,N,N-TMT (5-methyl-DMT; 5-Me-DMT), among others.[1]
It was first described in thescientific literature byRichard Glennon and colleagues by 1982.[2][3][4] However, 5-MeS-DMT wassynthesized and tested by Shulgin as early as 1979.[5]
