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5-MeO-DiBF

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
5-MeO-DiBF
Clinical data
Other names5-MeO-DIBF; 5-MeO-DiPBF; 5-Methoxy-N,N-diisopropyl-3-(2-aminoethyl)benzofuran; 5-Methoxy-N,N-diisopropyl-benzofuranethylamine; 1-Oxa-5-MeO-DiPT
Routes of
administration
Oral,insufflation[1]
Drug classSerotonergic psychedelic;Hallucinogen
ATC code
  • None
Legal status
Legal status
Pharmacokinetic data
Onset of action45 minutes[1]
Duration of action4–9 hours[1]
Identifiers
  • N-[2-(5-methoxy-1-benzofuran-3-yl)ethyl]-N-(propan-2-yl)propan-2-amine
CAS Number
  • None
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC17H25NO2
Molar mass275.392 g·mol−1
3D model (JSmol)
  • COC1=CC=C(OC=C2CCN(C(C)C)C(C)C)C2=C1
  • InChI=1S/C17H25NO2/c1-12(2)18(13(3)4)9-8-14-11-20-17-7-6-15(19-5)10-16(14)17/h6-7,10-13H,8-9H2,1-5H3
  • Key:NBFMSQBTYHYVKP-UHFFFAOYSA-N

5-MeO-DiBF, also known as5-methoxy-N,N-diisopropyl-3-(2-aminoethyl)benzofuran or as1-oxa-5-MeO-DiPT, is apsychedelic drug of thebenzofuran family related to the psychedelictryptamine5-MeO-DiPT.[2][1][3] It is theanalogue andbioisostere of 5-MeO-DiPT in which theindolenitrogen has been replaced with anoxygenatom, making it a benzofuran rather than tryptamine.[2] The drug has been sold online as a noveldesigner drug starting in 2015.[1][4]

Use and effects

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The dose of 5-MeO-DiBF has been given as 10 to 40 mgorally, with a light dose being 10 mg, a common dose being 20 mg, and a strong dose being 40 mg.[1] Itsonset is said to be 45 minutes and itsduration is variably said to be 4 to 9 hours.[1] In addition to oral administration, the drug may also beinsufflated.[1] The effects of 5-MeO-DiBF have been reported to includepsychedelic head space,tactile sensations andtingling, and increasedsexual desire, among others.[1]

Interactions

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See also:Psychedelic drug § Interactions, andTrip killer § Serotonergic psychedelic antidotes

Pharmacology

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Pharmacodynamics

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Analogues of 5-MeO-DiBF have been found to interact withserotonin receptors including theserotonin5-HT1A and5-HT2 receptors.[5][6]

Chemistry

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Analogues

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Analogues of 5-MeO-DiBF include thebenzofuransdimemebfe (5-MeO-BFE),MiPBF (1-oxa-MiPT),3-APB (1-oxa-AMT), andmebfap (5-MeO-3-APB; 1-oxa-5-MeO-AMT) and thetryptamine5-MeO-DiPT, among others.[3][2]

History

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5-MeO-DiBF has been sold online as adesigner drug and was first definitively identified in December 2015 by a forensic laboratory inSlovenia.[1][4]

Society and culture

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Legal status

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International

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5-MeO-DiBF is not controlled under theUnited Nations1971 Convention on Psychotropic Substances, so thus it has a legal grey area in manycountries, but it's possible it could be illegal under so-called analogue acts if sold for human consumption.[citation needed]

Armenia

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The drug is acontrolled substance inArmenia as of 2022.[7]

Canada

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5-MeO-DiBF is not acontrolled substance inCanada as of 2025.[8]

United States

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5-MeO-DiBF is not an explicitlycontrolled substance in theUnited States.[9] However, it could be considered a controlled substance under theFederal Analogue Act if intended for human consumption.

See also

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References

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  1. ^abcdefghijTrott DM (9 April 2019)."5-MeO-DiBF".The Drug Users Bible: Harm Reduction, Risk Mitigation, Personal Safety. MxZero Publishing.ISBN 978-0-9955936-8-8.
  2. ^abcAwuchi CG, Aja MP, Mitaki NB, Morya S, Amagwula IO, Echeta CK, et al. (2 February 2023)."New Psychoactive Substances: Major Groups, Laboratory Testing Challenges, Public Health Concerns, and Community-Based Solutions".Journal of Chemistry.2023:1–36.doi:10.1155/2023/5852315.ISSN 2090-9071.
  3. ^abCasale JF, Hays PA (2012)."The Characterization of 2-(5-Methoxy-1-benzofuran-3-yl)-N,N-dimethylethanamine (5-MeO-BFE) and Differentiation from its N-Ethyl Analog"(PDF).Microgram Journal.9 (1):39–45. Archived fromthe original(PDF) on 23 February 2015.
  4. ^ab"Europol 2015 Annual Report on the implementation of Council Decision 2005/387/JHA"(PDF). European Monitoring Center for Drugs and Drug Addiction.
  5. ^Tomaszewski Z, Johnson MP, Huang X, Nichols DE (May 1992). "Benzofuran bioisosteres of hallucinogenic tryptamines".Journal of Medicinal Chemistry.35 (11):2061–2064.doi:10.1021/jm00089a017.PMID 1534585.
  6. ^McKenna DJ, Repke DB, Lo L, Peroutka SJ (March 1990)."Differential interactions of indolealkylamines with 5-hydroxytryptamine receptor subtypes".Neuropharmacology.29 (3):193–198.doi:10.1016/0028-3908(90)90001-8.PMID 2139186.S2CID 24188017.
  7. ^"5-MeO-DIBF".АИПСИН (in Russian). Retrieved1 January 2026.
  8. ^"Controlled Drugs and Substances Act".Department of Justice Canada. Retrieved19 January 2026.
  9. ^Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026)(PDF),United States: U.S.Department of Justice:Drug Enforcement Administration (DEA): Diversion Control Division, January 2026

External links

[edit]
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