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5,7-Dichlorokynurenic acid

From Wikipedia, the free encyclopedia
5,7-Dichlorokynurenic acid
Names
Preferred IUPAC name
5,7-Dichloro-4-oxo-1,4-dihydroquinoline-2-carboxylic acid
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16) ☒N
    Key: BGKFPRIGXAVYNX-UHFFFAOYSA-N ☒N
  • InChI=1/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
    Key: BGKFPRIGXAVYNX-UHFFFAOYAD
  • C1=C(C=C2C(=C1Cl)C(=O)C=C(N2)C(=O)O)Cl
Properties
C10H5Cl2NO3
Molar mass258.05 g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound

5,7-Dichlorokynurenic acid (DCKA) is a selectiveNMDA receptor antagonist acting at theglycine site of theNMDA receptor complex.[1]

See also

[edit]

References

[edit]
  1. ^McNamara, D; Smith, EC; Calligaro, DO; O'Malley, PJ; McQuaid, LA; Dingledine, R (November 1990). "5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors".Neurosci. Lett.120:17–20.PMID 2149877.
AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor
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