Movatterモバイル変換

[0]ホーム
URL:

Jump to content
WikipediaThe Free Encyclopedia
Search

5α-Dihydrocorticosterone

From Wikipedia, the free encyclopedia
5α-Dihydrocorticosterone
Names
IUPAC name
11β,21-Dihydroxy-5α-pregnane-3,20-dione
Systematic IUPAC name
(1S,3aS,3bS,5aS,9aS,9bS,10S,11aS)-10-Hydroxy-1-(hydroxyacetyl)-9a,11a-dimethylhexadecahydro-7H-cyclopenta[a]phenanthren-7-one
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C21H32O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h12,14-17,19,22,24H,3-11H2,1-2H3/t12-,14-,15-,16+,17-,19+,20-,21-/m0/s1
  • CC12CCC(=O)CC1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O
Properties
C21H32O4
Molar mass348.47638 g/mol
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

5α-Dihydrocorticosterone (5α-DHC,5α-DHB), also known as11β,21-dihydroxy-5α-pregnane-3,20-dione, is anaturally occurring,endogenousglucocorticoidsteroid hormone andneurosteroid.[1][2][3] It isbiosynthesized fromcorticosterone by theenzyme5α-reductase.[4][5][6] DHC hascentral depressant effects and impairslong-term potentiation in animals.[7][8]

See also

[edit]

References

[edit]
  1. ^R.A. Hill; H.L.J. Makin; D.N. Kirk; G.M. Murphy (23 May 1991).Dictionary of Steroids. CRC Press. pp. 218–.ISBN 978-0-412-27060-4.
  2. ^McInnes, K. J.; Kenyon, C. J.; Chapman, K. E.; Livingstone, D. E. W.; Macdonald, L. J.; Walker, B. R.; Andrew, R. (2004)."5 -Reduced Glucocorticoids, Novel Endogenous Activators of the Glucocorticoid Receptor".Journal of Biological Chemistry.279 (22):22908–22912.doi:10.1074/jbc.M402822200.ISSN 0021-9258.PMID 15044432.
  3. ^Magnaghi V (2007)."GABA and neuroactive steroid interactions in glia: new roles for old players?".Curr Neuropharmacol.5 (1):47–64.doi:10.2174/157015907780077132.PMC 2435342.PMID 18615153.
  4. ^Abraham Weizman (1 February 2008).Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders: Novel Strategies for Research and Treatment. Springer Science & Business Media. pp. 48–.ISBN 978-1-4020-6854-6.
  5. ^Neurosteroids and Brain Function. Academic Press. 12 December 2001. pp. 147–.ISBN 978-0-08-054423-6.
  6. ^N. Kato; M. Kawata; R.K. Pitman (3 July 2007).PTSD: Brain Mechanisms and Clinical Implications. Springer Science & Business Media. pp. 125–.ISBN 978-4-431-29567-9.
  7. ^Dubrovsky, B.; Williams, D.; Kraulis, I. (1985). "Effects of corticosterone and 5?-dihydrocorticosterone on brain excitability in the rat".Journal of Neuroscience Research.14 (1):117–128.doi:10.1002/jnr.490140111.ISSN 0360-4012.PMID 4020896.S2CID 84291184.
  8. ^Dubrovsky, B.O.; Liquornik, M.S.; Noble, P.; Gijsbers, K. (1987). "Effects of 5α-dihydrocorticosterone on evoked responses and long-term potentiation".Brain Research Bulletin.19 (6):635–638.doi:10.1016/0361-9230(87)90049-9.ISSN 0361-9230.PMID 3440216.S2CID 54274436.
Precursors
Corticosteroids
Glucocorticoids
Mineralocorticoids
Sex steroids
Androgens
Estrogens
Progestogens
Neurosteroids
Others
GRTooltip Glucocorticoid receptor
Agonists
Mixed
(SEGRMsTooltip Selective glucocorticoid receptor agonists)
Antagonists
Others


This article about apregnanes is astub. You can help Wikipedia byadding missing information.

Retrieved from "https://en.wikipedia.org/w/index.php?title=5α-Dihydrocorticosterone&oldid=1308593586"
Categories:
Hidden categories:
[8]ページ先頭
©2009-2026 Movatter.jp