40S ribosomal protein S8 is aprotein that in humans is encoded by theRPS8gene.[5][6]
Ribosomes, theorganelles thatcatalyzeprotein synthesis, consist of asmall 40S subunit and alarge 60S subunit. Together these subunits are composed of 4RNA species and approximately 80 structurally distinct proteins. This gene encodes aribosomal protein that is a component of the 40S subunit. The protein belongs to the S8E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene incolorectal tumors andcolon polyps compared to matched normalcolonic mucosa has been observed. This gene is co-transcribed with thesmall nucleolar RNA genes U38A, U38B, U39, and U40, which are located in its fourth, fifth, first, and second introns, respectively. As is typical for genes encodingribosomal proteins, there are multiple processedpseudogenes of this gene dispersed through the genome.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Davies B, Fried M (Mar 1993). "The structure of the human intron-containing S8 ribosomal protein gene and determination of its chromosomal location at 1p32-p34.1".Genomics.15 (1):68–75.doi:10.1006/geno.1993.1011.PMID8432552.
Nicoloso M, Qu LH, Michot B, Bachellerie JP (1996). "Intron-encoded, antisense small nucleolar RNAs: the characterization of nine novel species points to their direct role as guides for the 2'-O-ribose methylation of rRNAs".J. Mol. Biol.260 (2):178–95.doi:10.1006/jmbi.1996.0391.PMID8764399.
