 | |
| Names | |
|---|---|
| IUPAC name 4-Methoxyestra-1,3,5(10)-triene-3,16α,17β-triol | |
| Systematic IUPAC name (1R,2R,3aS,3bR,9bS,11aS)-6-Methoxy-11a-methyl-2,3,3a,3b,4,5,9b,10,11,11a-decahydro-1H-cyclopenta[a]phenanthrene-1,2,7-triol | |
| Other names 4-MeO-E3 | |
| Identifiers | |
3D model (JSmol) | |
| ChemSpider | |
| |
| |
| Properties | |
| C19H26O4 | |
| Molar mass | 318.413 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
4-Methoxyestriol (4-MeO-E3) is anendogenousestrogenmetabolite.[1][2][3][4] It is the 4-methylether of4-hydroxyestriol and a metabolite ofestriol and 4-hydroxyestriol.[1][2][3] 4-Methoxyestriol has very lowaffinities for theestrogen receptors.[4] Itsrelative binding affinities (RBAs) forestrogen receptor alpha (ERα) andestrogen receptor beta (ERβ) are both about 1% of those ofestradiol.[4] For comparison, estriol had RBAs of 11% and 35%, respectively.[4]