| 4-hydroxybutyrate dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifiers | |||||||||
| EC no. | 1.1.1.61 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDBPDBePDBsum | ||||||||
| Gene Ontology | AmiGO /QuickGO | ||||||||
| |||||||||
Inenzymology, a4-hydroxybutyrate dehydrogenase (EC1.1.1.61) is anenzyme thatcatalyzes thechemical reaction
The twosubstrates of this enzyme are 4-hydroxybutanoic acid, and oxidisednicotinamide adenine dinucleotide (NAD+). Itsproducts are succinic semialdehyde, reduced NADH, and aproton.[1]
This enzyme belongs to the family ofoxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.[2] Thesystematic name of this enzyme class is4-hydroxybutanoate:NAD+ oxidoreductase. This enzyme is also calledgamma-hydroxybutyrate dehydrogenase. This enzyme participates inbutanoate metabolism and the degradation of theneurotransmitter4-hydroxybutanoic acid.[3]
