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4-HO-NET

From Wikipedia, the free encyclopedia

Pharmaceutical compound
4-HO-NET
Clinical data
Other names4-Hydroxy-N-ethyltryptamine
Drug classSerotonin receptor modulator;Serotonin 5-HT2A receptor agonist;Serotonergic psychedelic;Hallucinogen
ATC code
  • None
Identifiers
  • 3-[2-(ethylamino)ethyl]-1H-indol-4-ol
PubChemCID
ChemSpider
Chemical and physical data
FormulaC12H16N2O
Molar mass204.273 g·mol−1
3D model (JSmol)
  • CCNCCC1=CNC2=C1C(=CC=C2)O
  • InChI=1S/C12H16N2O/c1-2-13-7-6-9-8-14-10-4-3-5-11(15)12(9)10/h3-5,8,13-15H,2,6-7H2,1H3
  • Key:AGYHPYWJOGSFII-UHFFFAOYSA-N

4-HO-NET, also known as4-hydroxy-N-ethyltryptamine, is aserotonin receptor modulator and putativepsychedelic drug of thetryptamine and4-hydroxytryptamine families related tonorpsilocin (4-HO-NMT).[1] It was not included byAlexander Shulgin in his 1997 bookTiHKAL (Tryptamines I Have Known and Loved) and its properties and effects in humans are unknown.[2] The drug acts as anon-selectiveserotonin receptor agonist, including of theserotonin5-HT2A receptor.[1] It produces thehead-twitch response, a behavioral proxy of psychedelic effects, in rodents, albeit with about 13-fold lowerpotency thanpsilocin (4-HO-DMT).[1] Unlike 4-HO-NET, norpsilocin is notably inactive in this test.[1] In addition to its psychedelic-like effects, 4-HO-NET produceshypolocomotion andhypothermia in rodents.[1] 4-HO-NET was first described in thescientific literature by Alexander Sherwood and colleagues by 2024.[1]

See also

[edit]

References

[edit]
  1. ^abcdefSherwood AM, Burkhartzmeyer EK, Williamson SE, Baumann MH, Glatfelter GC (January 2024)."Psychedelic-like Activity of Norpsilocin Analogues".ACS Chemical Neuroscience.15 (2):315–327.doi:10.1021/acschemneuro.3c00610.PMC 10797613.PMID 38189238.
  2. ^Shulgin A,Shulgin A (September 1997).TiHKAL: The Continuation.Berkeley, California:Transform Press.ISBN 0-9630096-9-9.OCLC 38503252.

External links

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