4-AcO-MET

Clinical data
Other names	4-Acetoxy-MET; 4-Acetoxy-N-methyl-N-ethyltryptamine; Metacetin
Routes of administration	Oral[1]
Drug class	Serotonergic psychedelic;Hallucinogen
ATC code	None
Legal status
Legal status	BR: Class F2 (Prohibited psychotropics)[2]
Pharmacokinetic data
Duration of action	4–10 hours[1]
Identifiers
IUPAC name [3-[2-[ethyl(methyl)amino]ethyl]-1H-indol-4-yl] acetate
CAS Number	1445751-40-5
PubChemCID	71308138
ChemSpider	26633897
UNII	PCJ17NV1P0
CompTox Dashboard(EPA)	DTXSID301029955
Chemical and physical data
Formula	C15H20N2O2
Molar mass	260.337 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCN(C)CCc1c[nH]c2c1c(ccc2)OC(=O)C
InChI InChI=1S/C15H20N2O2/c1-4-17(3)9-8-12-10-16-13-6-5-7-14(15(12)13)19-11(2)18/h5-7,10,16H,4,8-9H2,1-3H3 Key:OMDKHOOGGJRLLX-UHFFFAOYSA-N

4-AcO-MET, also known as4-acetoxy-N-methyl-N-ethyltryptamine ormetacetin, is apsychedelic drug of thetryptamine family.^[1] It is theacetateester of4-HO-MET, and ahomologue of4-AcO-DMT.^[1] The drug is a novel compound with very little history of human use.^[3] It has been encountered as a noveldesigner drug.^[3][1]

4-AcO-MET is thought to be aprodrug of4-HO-MET.^[1] The dose of 4-AcO-MET is said to be 5 to 40 mgorally and itsduration is said to be 4 to 10 hours.^[1] It is said to producepsilocin (4-HO-DMT)-likepsychedelic effects.^[1]

Due to its similarity to thepsilocinprodrug 4-AcO-DMT, which isdeacetylated to form psilocinin vivo,^[4][5] it is expected that 4-AcO-MET is also quicklyhydrolyzed into4-HO-MET byserumesterases, but human studies concerning themetabolic fate of this drug are lacking.

Thepharmacology of 4-AcO-MET has been studied.^[6][7]

Analogues of 4-AcO-MET includemethylethyltryptamine (MET),4-HO-MET (metocin),5-MeO-MET,4-AcO-DMT (psilacetin),4-AcO-DET (ethacetin),4-AcO-MPT, and4-PrO-MET, among others.

4-AcO-MET was encountered as a noveldesigner drug inEurope in 2009.^[3]

4-AcO-MET is not acontrolled substance inCanada as of 2025.^[8]

In Switzerland, 4-AcO-MET is a controlled substance under Verzeichnis E.^[9]

In the United Kingdom, 4-AcO-MET is a Class A drug in the United Kingdom because it is anester of the drug 4-HO-MET, which is a Class A drug under the tryptamine catch-all clause.^[10]

In the United States, 4-AcO-MET is not scheduled. It may be considered an analogue ofpsilocin, a Schedule I drug under theControlled Substances Act.^[11] As such, the sale for human consumption or the use for illicit non-medical purposes could be considered a crime under the Federal Analogue Act.^[12]

• Substituted tryptamine

• 4-AcO-MET - Isomer Design
• 4-AcO-MET - PsychonautWiki
• The Big & Dandy 4-AcO-MET Thread - Bluelight

• Drugs not assigned an ATC code
• 5-HT2A agonists
• Acetate esters
• 4-Acyloxytryptamines
• Designer prodrugs
• N,N-Dialkyltryptamines
• Psychedelic tryptamines

• CS1 Russian-language sources (ru)
• CS1 Brazilian Portuguese-language sources (pt-br)
• Articles with short description
• Short description matches Wikidata
• Short description is different from Wikidata
• Articles without EBI source
• Chemical pages without DrugBank identifier
• Articles without KEGG source
• Articles containing unverified chemical infoboxes