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4-AcO-MALT

From Wikipedia, the free encyclopedia

Pharmaceutical compound
4-AcO-MALT
Clinical data
Other names4-Acetoxy-MALT; 4-Acetoxy-N-methyl-N-allyltryptamine
Routes of
administration
Oral
Drug classSerotonin receptor modulator;Serotonergic psychedelic;Hallucinogen
ATC code
  • None
Identifiers
CAS Number
PubChemCID
ChemSpider
UNII
Chemical and physical data
FormulaC16H20N2O2
Molar mass272.348 g·mol−1
3D model (JSmol)
  • C=CCN(CCc1c[nH]c2c1c(ccc2)OC(=O)C)C
  • InChI=InChI=1S/C16H20N2O2/c1-4-9-18(3)10-8-13-11-17-14-6-5-7-15(16(13)14)20-12(2)19/h4-7,11,17H,1,8-10H2,2-3H3
  • Key:PGBFYUDKPCYIEB-UHFFFAOYSA-N

4-AcO-MALT, also known as4-acetoxy-N-methyl-N-allyltryptamine, is apsychedelic drug of thetryptamine family.[1][2][3] It is theacetateester of4-HO-MALT.[1][2][3]

Use and effects

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See also:4-HO-MALT § Use and effects

Interactions

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See also:Psychedelic drug § Interactions, andTrip killer § Serotonergic psychedelic antidotes

Pharmacology

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Pharmacodynamics

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4-AcO-MALT is assumed to act as aprodrug of theserotonergic psychedelic 4-HO-MALT.[1] 4-HO-MALT is aserotonin receptor modulator, including acting as anagonist of theserotonin5-HT2 receptors.[2] Thereceptor interactions of 4-AcO-MALT have also been studied.[2][3]

Chemistry

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Analogues

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Analogues of 4-AcO-MALT includemethylallyltryptamine (MALT),4-HO-MALT (maltocin),5-MeO-MALT,4-AcO-DMT (psilacetin),4-AcO-MET (metacetin),4-AcO-MPT,4-AcO-MiPT (mipracetin), and4-AcO-DALT, among others.

History

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4-AcO-MALT was first described in thescientific literature by at least 2021.[1] It has been encountered as a noveldesigner drug.[4][5]

See also

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References

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  1. ^abcdPham DN, Chadeayne AR, Golen JA, Manke DR (1 February 2021)."Psilacetin derivatives: fumarate salts of the methyl–ethyl, methyl–allyl and diallyl variants of the psilocin prodrug".Acta Crystallographica Section E.77 (Pt 2):101–106.Bibcode:2021AcCrE..77..101P.doi:10.1107/S2056989021000116.ISSN 2056-9890.PMC 7869532.PMID 33614134.
  2. ^abcdGlatfelter GC, Naeem M, Pham DN, Golen JA, Chadeayne AR, Manke DR, et al. (April 2023)."Receptor Binding Profiles for Tryptamine Psychedelics and Effects of 4-Propionoxy-N,N-dimethyltryptamine in Mice".ACS Pharmacology & Translational Science.6 (4):567–577.doi:10.1021/acsptsci.2c00222.PMC 10111620.PMID 37082754.
  3. ^abcJain MK, Gumpper RH, Slocum ST, Schmitz GP, Madsen JS, Tummino TA, et al. (July 2025)."The polypharmacology of psychedelics reveals multiple targets for potential therapeutics"(PDF).Neuron.doi:10.1016/j.neuron.2025.06.012.PMID 40683247.
  4. ^Miller JJ, Yazdanpanah M, Colantonio DA, Beriault DR, Delaney SR (2024). "New Psychoactive Substances: A Canadian perspective on emerging trends and challenges for the clinical laboratory".Clinical Biochemistry.133–134 110810.doi:10.1016/j.clinbiochem.2024.110810.PMID 39181179.
  5. ^Axelsson MA, Lövgren H, Kronstrand R, Green H, Bergström MA (2022)."Retrospective identification of new psychoactive substances in patient samples submitted for clinical drug analysis".Basic & Clinical Pharmacology & Toxicology.131 (5):420–434.doi:10.1111/bcpt.13786.ISSN 1742-7835.PMID 36028947.

External links

[edit]
Tryptamines
No ring subs.
4-Hydroxytryptamines
5-Hydroxytryptamines
5-Methoxytryptamines
Other ring subs.
α-Alkyltryptamines
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Bioisosteres
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5-HT1
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5-HT2C
5-HT37
5-HT3
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5-HT5A
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Tryptamines
4-Hydroxytryptamines
andesters/ethers
5-Hydroxy- and
5-methoxytryptamines
N-Acetyltryptamines
α-Alkyltryptamines
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Isotryptamines
Related compounds
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