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3152 CT

From Wikipedia, the free encyclopedia
3152 CT
Names
Preferred IUPAC name
3-[(Dimethylcarbamoyl)oxy]-N,N,N-trimethyl-5-{3-[3-(trimethylazaniumyl)phenoxy]propoxy}anilinium diiodide
Identifiers
3D model (JSmol)
  • InChI=1S/C18H23N3O4.2HI/c1-21(2)18(22)25-17-11-14(20)10-16(12-17)24-8-4-7-23-15-6-3-5-13(19)9-15;;/h3,5-6,9-12H,4,7-8,19-20H2,1-2H3;2*1H
    Key: KDBKYZAHSYSXLC-UHFFFAOYSA-N
  • [NH3+]c(c1)cccc1OCCCOc(cc([NH3+])c2)cc2OC(=O)N(C)C.[I-].[I-]
Properties
C24H37I2N3O4
Molar mass685.386 g·mol−1
AppearanceSolid[1]
Melting point182–184[1] °C (360–363 °F; 455–457 K)
Hazards
Lethal dose or concentration (LD, LC):
16 μg/kg (intravenous, mice)[1]
8 μg/kg (intravenous, rabbits)[1]
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

3152 CT is an extremely toxicbisquaternarycarbamate with powerfulanticholinesterase action.[2] It has an LD50 in rats and rabbits 10 times lower than that of the GB agent and, on a molar basis, is 30 times more toxic than the latter.[3]

See also

[edit]

References

[edit]
  1. ^abcd"Method for methylating and quaternizing".
  2. ^LEVIN, AP; JANDORF, BJ (February 1955). "Inactivation of cholinesterase by compounds related to neostigmine".The Journal of Pharmacology and Experimental Therapeutics.113 (2):206–11.doi:10.1016/S0022-3565(25)11504-8.PMID 13234044.
  3. ^WILLIAM H. SUMMERSON - Deputy Commander for Scientific Activities, USA CmIC Research and Development Command, Washington, D. C..The Chemical Warfare Threat. NONMILITARY DEFENSE - Chemical and Biological Defenses in Perspective. ACS, 1960.
Enzyme
(modulators)
ChATTooltip Choline acetyltransferase
AChETooltip Acetylcholinesterase
BChETooltip Butyrylcholinesterase
Transporter
(modulators)
CHTTooltip Choline transporter
VAChTTooltip Vesicular acetylcholine transporter
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