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3-Pyrrolylpropylamine

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(Redirected from3-pyrrolylpropylamine)

Pharmaceutical compound
3-Pyrrolylpropylamine
Clinical data
Other namesα-Methyl-3-pyrrolylethylamine; 3-Pyrrolepropylamine
Identifiers
  • 1-(1H-pyrrol-3-yl)propan-2-amine
CAS Number
PubChemCID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC7H12N2
Molar mass124.187 g·mol−1
3D model (JSmol)
  • CC(CC1=CNC=C1)N
  • InChI=1S/C7H12N2/c1-6(8)4-7-2-3-9-5-7/h2-3,5-6,9H,4,8H2,1H3
  • Key:XMTHAWZPEGHZPK-UHFFFAOYSA-N

3-Pyrrolylpropylamine, also known asα-methyl-3-pyrrolylethylamine, is achemical compound of thearylalkylamine family.[1] It is theanalogue of theserotonergic psychedelicα-methyltryptamine (AMT) in which thebenzene component of theindolering has been removed.[1]

In contrast totryptamines like AMT, 3-pyrrolylpropylamine does not bind to theserotonin5-HT1A or5-HT2A receptors (Ki = >10,000 nM).[1] These findings suggest that the benzene part of the indole ring is required for significant binding toserotonin receptors and by extensionpsychedelic activity.[1] The activities of 3-pyrrolylpropylamine at othertargets, such as themonoamine transporters, were not reported.[1]

3-Pyrrolylpropylamine was first described in thescientific literature by at least 1990.[1]

See also

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References

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  1. ^abcdefGlennon RA, Chaurasia C, Titeler M (October 1990). "Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region".Journal of Medicinal Chemistry.33 (10):2777–2784.doi:10.1021/jm00172a016.PMID 2213830.

External links

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