| 3-α,7-α-Dihydroxy-5-β-cholestanate—CoA ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 6.2.1.28 | ||||||||
| CAS no. | 118732-03-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDBPDBePDBsum | ||||||||
| Gene Ontology | AmiGO /QuickGO | ||||||||
| |||||||||
Inenzymology, a3α,7α-dihydroxy-5β-cholestanate—CoA ligase (EC6.2.1.28) is anenzyme thatcatalyzes thechemical reaction
The 3substrates of this enzyme areATP,(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate, andCoA, whereas its 3products areAMP,diphosphate, and(25R)-3alpha,7alpha-dihydroxy-5beta-cholestanoyl-CoA.
This enzyme belongs to the family ofligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. Thesystematic name of this enzyme class is(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate:CoA ligase (AMP-forming). Other names in common use include3alpha,7alpha-dihydroxy-5beta-cholestanoyl coenzyme A synthetase,DHCA-CoA ligase, and3alpha,7alpha-dihydroxy-5beta-cholestanate:CoA ligase (AMP-forming). This enzyme participates inbile acid biosynthesis.
