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3-Isopropylmalate dehydratase

From Wikipedia, the free encyclopedia
Class of enzymes
3-isopropylmalate dehydratase
Identifiers
EC no.4.2.1.33
CAS no.37290-72-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
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Gene OntologyAmiGO /QuickGO
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NCBIproteins

3-Isopropylmalate dehydratase (EC4.2.1.33) is anaconitase homologue,[1][2][3] which catalyses the isomerisation of2-isopropylmalate to 3-isopropylmalate, viadehydration, in the biosynthesis ofleucine.

References

[edit]
  1. ^Gross SR, Burns RO, Umbarger HE (1963). "The biosynthesis of leucine. II. The enzymic isomerization of beta-carboxy-beta-hydroxyisocaproate and alpha-hydroxy-beta-carboxyisocaproate".Biochemistry.2 (5):1046–52.doi:10.1021/bi00905a023.PMID 14087357.
  2. ^Calvo JM, Stevens CM, Kalyanpur MG, Umbarger HE (December 1964). "The absolute configuration of alpha-hydroxy-beta-carboxyisocaproic acid (3-isopropylmalic acid), an intermediate in leucine biosynthesis".Biochemistry.3 (12):2024–7.doi:10.1021/bi00900a043.PMID 14269331.
  3. ^Cole FE, Kalyanpur MG, Stevens CM (August 1973). "Absolute configuration of alpha isopropylmalate and the mechanism of its conversion to beta isopropylmalate in the biosynthesis of leucine".Biochemistry.12 (17):3346–50.doi:10.1021/bi00741a031.PMID 4270046.

External links

[edit]
Carbon–oxygenlyases (EC 4.2) (primarilydehydratases)
4.2.1:Hydro-Lyases
4.2.2: Acting on polysaccharides
4.2.3: Acting on phosphates
4.2.99: Other


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