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2CT2-2-EtO

From Wikipedia, the free encyclopedia
Pharmaceutical compound
2CT2-2-EtO
Clinical data
Other names2CT2-2EtO; 2-Ethoxy-4-ethylthio-5-methoxyphenethylamine
Routes of
administration
Oral,intranasal[1]
Drug classSerotonergic psychedelic;Hallucinogen
ATC code
  • None
Pharmacokinetic data
Onset of action"Very quick"[1]
Duration of action5–9 hours[1]
Identifiers
  • 2-(2-ethoxy-4-ethylsulfanyl-5-methoxyphenyl)ethanamine
PubChemCID
Chemical and physical data
FormulaC13H21NO2S
Molar mass255.38 g·mol−1
3D model (JSmol)
  • CCOC1=CC(=C(C=C1CCN)OC)SCC
  • InChI=1S/C13H21NO2S/c1-4-16-11-9-13(17-5-2)12(15-3)8-10(11)6-7-14/h8-9H,4-7,14H2,1-3H3
  • Key:KVHWZNAVMLBLMV-UHFFFAOYSA-N

2CT2-2-EtO, also known as2-ethoxy-4-ethylthio-5-methoxyphenethylamine, is apsychedelic drug of thephenethylamine,2C, andTWEETIO families related to2C-T-2.[1][2][3] It is thederivative of 2C-T-2 in which themethoxy group at the 2 position has been replaced with anethoxy group.[1][2][3]

According toAlexander Shulgin in his bookPiHKAL (Phenethylamines I Have Known and Loved) and other publications, 2CT2-2-EtO has a "completely effective" dose of 50 mgorally, a typical dose of 10 mgintranasally but with considerable variation between individuals, and aduration of 5 to 6 hours or of 9 hours.[1][2][3] Itsonset is said to be "very quick".[1] The effects of 2CT2-2EtO have been reported to includeblurred vision, intenseclosed-eye visuals, generation of a pleasant and contemplativemood,restlesssleep, andweird dreams.[1] Due to the large ~5-fold increase inpotency when taken intranasally instead of orally, 2CT2-2EtO may undergo substantialfirst-pass metabolism with oral administration.[3]

Thechemical synthesis of 2CT2-2-EtO has been described.[1]

2CT2-2-EtO was first described in the literature by Shulgin inPiHKAL in 1991.[1] It was developed and tested byDarrell Lemaire, with publication via personal communication with Shulgin.[2][4][5][6][7] The drug is acontrolled substance inCanada under phenethylamine blanket-ban language.[8]

See also

[edit]

References

[edit]
  1. ^abcdefghijShulgin, Alexander;Shulgin, Ann (September 1991).PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press.ISBN 0-9630096-0-5.OCLC 25627628. "All three Tweetios of 2C-T-2 have been made and looked at through human eyes. The 2-EtO-homologue of 2C-T-2 is 2-ethoxy-4-ethylthio-5-methoxyphenethylamine, or 2CT2-2ETO. The benzaldehyde (2-ethoxy-4-ethylthio-5-methoxybenzaldehyde) had a melting point of 73-75 °C, the nitrostyrene intermediate a melting point of 122-123 °C, and the final hydrochloride a melting point of 202-204 °C. Fifty milligrams was a completely effective level. The effects were felt very quickly. Vision was blurred, and there were intense eyes-closed visuals and the generation of a pleasant, contemplative mood. Baseline was re-established in five or six hours, but sleep was restless, with weird dreams. Nasal administration showed considerable variation between individuals, but a typical dose was 10 milligrams."
  2. ^abcdShulgin AT (2003)."Basic Pharmacology and Effects". In Laing RR (ed.).Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. pp. 67–137.ISBN 978-0-12-433951-4. Archived fromthe original on 13 July 2025.
  3. ^abcdTrachsel D, Lehmann D, Enzensperger C (2013).Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag.ISBN 978-3-03788-700-4.OCLC 858805226. Archived fromthe original on 21 August 2025.
  4. ^"Erowid Darrell Lemaire Vault".erowid.org. Retrieved14 November 2025.
  5. ^Morris H (7 December 2016)."The Lazy Lizard School of Hedonism".Hamilton's Pharmacopeia. Season 1. Episode 6.Vice Media.Viceland.
  6. ^Nez H,Lemaire D (2010)."Notes About Psychoactive Compounds"(PDF). In Targ R, Radin D (eds.).Radiant Minds: Scientists Explore the Dimensions of Consciousness. Millay. pp. 201–207.ISBN 978-0-615-29633-3.
  7. ^Lazar (Darrell Lemaire); Hosteen Nez (1990).Certain Exotic Transmitters as Smart Pills or Compounds that Increase the Capacity for Mental Work in Humans: A Story About LAZAR as Told by Hosteen Nez (2nd ed.). Archived fromthe original(PDF) on 9 July 2001.
  8. ^"Controlled Drugs and Substances Act".Department of Justice Canada. Retrieved19 January 2026.

External links

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