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2CD-5EtO

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(Redirected from2CD-5-EtO)
Chemical compound

Pharmaceutical compound
2CD-5EtO
Clinical data
Other names2C-D-5-EtO; 2CD-5-EtO; 5-Ethoxy-2-methoxy-4-methylphenethylamine; 2-Methoxy-5-ethoxy-4-methylphenethylamine; 4-Methyl-2-methoxy-5-ethoxyphenethylamine; 2-Methoxy-4-methyl-5-ethoxyphenethylamine
Routes of
administration
Oral[1]
Drug classSerotonergic psychedelic;Hallucinogen
Pharmacokinetic data
Onset of action~2 hours (peak)[1]
Duration of action12 hours[1][2][3]
Identifiers
  • 1-(5-ethoxy-2-methoxy-4-methylphenyl)-ethan-1-amine
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC12H19NO2
Molar mass209.289 g·mol−1
3D model (JSmol)
  • CCOC1=CC(=C(C=C1C)OC)CCN
  • InChI=1S/C12H19NO2/c1-4-15-11-8-10(5-6-13)12(14-3)7-9(11)2/h7-8H,4-6,13H2,1-3H3 checkY
  • Key:ZMQDQUPRBYFPSO-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

2CD-5EtO, also known as5-ethoxy-2-methoxy-4-methylphenethylamine, is apsychedelic drug of thephenethylamine,2C, andTWEETIO families related to2C-D.[1][2][3] It is theanalogue of 2C-D in which themethoxy group at the 5 position has been extended to anethoxy group.[1][2][3]

Use and effects

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In his bookPiHKAL (Phenethylamines I Have Known and Loved) and other publications,Alexander Shulgin lists 2CD-5EtO's dose as 40 to 50 mgorally, itsonset as slow and gradual, its time to peak or full effects as about 2 hours, and itsduration as 12 hours.[1][2][3] The effects of 2CD-5EtO were said to include being "largely free from excitement", having "a friendly openness and outgoingness that allowed easy talk, interaction, humor", and allowing for healthy appetite.[1]

Interactions

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See also:Psychedelic drug § Interactions, andTrip killer § Serotonergic psychedelic antidotes

Chemistry

[edit]

Synthesis

[edit]

Thechemical synthesis of 2CD-5EtO has been described.[1]

History

[edit]

2CD-5EtO was first described in the literature byAlexander Shulgin in his bookPiHKAL (Phenethylamines I Have Known and Loved) in 1991.[1] It was developed and tested byDarrell Lemaire, with publication via personal communication with Shulgin.[2][4][5][6][7]

Society and culture

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Legal status

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2CD-5EtO is acontrolled substance inCanada under phenethylamine blanket-ban language.[8]

See also

[edit]

References

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  1. ^abcdefghiShulgin A,Shulgin A (September 1991).PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press.ISBN 0-9630096-0-5.OCLC 25627628.https://www.erowid.org/library/books_online/pihkal/pihkal023.shtml#:~:text=2CD%2D5ETO
  2. ^abcdeShulgin AT (2003)."Basic Pharmacology and Effects". In Laing RR (ed.).Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. pp. 67–137.ISBN 978-0-12-433951-4. Archived fromthe original on 13 July 2025.
  3. ^abcdJacob P, Shulgin AT (1994)."Structure-activity relationships of the classic hallucinogens and their analogs".NIDA Research Monograph.146:74–91.PMID 8742795.
  4. ^"Erowid Darrell Lemaire Vault".erowid.org. Retrieved14 November 2025.
  5. ^Morris H (7 December 2016)."The Lazy Lizard School of Hedonism".Hamilton's Pharmacopeia. Season 1. Episode 6.Vice Media.Viceland.
  6. ^Nez H,Lemaire D (2010)."Notes About Psychoactive Compounds"(PDF). In Targ R, Radin D (eds.).Radiant Minds: Scientists Explore the Dimensions of Consciousness. Millay. pp. 201–207.ISBN 978-0-615-29633-3.
  7. ^Lazar (Darrell Lemaire), Hosteen Nez (1990).Certain Exotic Transmitters as Smart Pills or Compounds that Increase the Capacity for Mental Work in Humans: A Story About LAZAR as Told by Hosteen Nez (2nd ed.). Archived fromthe original(PDF) on 9 July 2001.
  8. ^"Controlled Drugs and Substances Act".Department of Justice Canada. Retrieved19 January 2026.

External links

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