2C-T-7

Clinical data
Other names	2,5-Dimethoxy-4-propylthiophenethylamine; 2,5-Dimethoxy-4-propylsulfanylphenethylamine; 4-Propylthio-2,5-dimethoxyphenethylamine; 4-Propylsulfanyl-2,5-dimethoxyphenethylamine; Blue Mystic; Tweety-Bird Mescaline
Routes of administration	Oral[1]
Drug class	Serotonin5-HT2 receptoragonist;Serotonergic psychedelic;Hallucinogen
ATC code	None
Legal status
Legal status	BR: Class F2 (Prohibited psychotropics) CA: Schedule III US: Schedule I
Pharmacokinetic data
Duration of action	8–15 hours[1]
Identifiers
IUPAC name 2-[2,5-dimethoxy-4-(propylsulfanyl)phenyl]ethan-1-amine
CAS Number	207740-26-9 Y
PubChemCID	24728635
ChemSpider	21106233 Y
UNII	TJG366J9BA
KEGG	C22737
ChEMBL	ChEMBL126432 Y
CompTox Dashboard(EPA)	DTXSID90861566
Chemical and physical data
Formula	C13H21NO2S
Molar mass	255.38 g·mol−1
3D model (JSmol)	Interactive image
Melting point	206 to 207 °C (403 to 405 °F)
SMILES COc1cc(SCCC)c(cc1CCN)OC
InChI InChI=1S/C13H21NO2S/c1-4-7-17-13-9-11(15-2)10(5-6-14)8-12(13)16-3/h8-9H,4-7,14H2,1-3H3 Y Key:OLEVEPDJOFPJTF-UHFFFAOYSA-N Y
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2C-T-7, also known as4-propylthio-2,5-dimethoxyphenethylamine or asBlue Mystic or7th Heaven, is apsychedelic drug of thephenethylamine and2C families.^[1][2][3][4] It is takenorally.^[1]

2C-T-7 was first described in thescientific literature byMyron Stolaroff in 1990.^[5] It was developed byAlexander Shulgin and colleagues and was described in greater detail by them in 1991, including in Shulgin's bookPiHKAL (Phenethylamines I Have Known and Loved).^[5][6][1]

In his bookPiHKAL (Phenethylamines I Have Known and Loved),Alexander Shulgin lists 2C-T-7's dose range as 10 to 30 mgorally and itsduration as 8 to 15 hours.^[1] It producespsychedelic effects.^[1][5][7][8] InPiHKAL, Shulgin records that thehallucinations it produces are unique, and that the chemical may cause muscle tension and an altered vocal quality.^[9] Shulgin rated it as one of the "magical half-dozen" most important psychedelic phenethylamines, together withmescaline,2C-B, and2C-T-2.^[1]

2C-T-7 ismetabolized by themonoamine oxidase (MAO)enzymesMAO-A andMAO-B.^[10][11]Monoamine oxidase inhibitors (MAOIs) such asphenelzine,tranylcypromine,moclobemide, andselegiline may potentiate the effects of 2C-T-7.^[10][11][12] This may result inoverdose and serioustoxicity.^[12][10]

There have been at least three reported deaths related to 2C-T-7 use as of August 2007, mainly atinsufflated (snorted) doses of 30 mg or more.^[13][14] In the fall of 2000, a young healthy male died following insufflation of an excessive amount of 2C-T-7. Two additional deaths reported in April 2001 have been linked to 2C-T-7. These two deaths were reported by the DEA as being the result of the co-abuse of 2C-T-7 with MDMA.^[15]

In January 2002,Rolling Stone published an article about 2C-T-7 entitled "The New (legal) Killer Drug".^[16] Although the article suggested that the drug was legal, the legal status of 2C-T-7 was ambiguous at the time due to the United States'Federal Analogue Act.^[17] A detailed response on the websitedisinfo.com challenged the accuracy of much of the reporting in the aforementionedRolling Stone article.^[18] 2C-T-7 has since been officially made illegal and declared a schedule 1 substance in the United States.^[19]

ThePartnership for a Drug-Free America reported in 2006 that 2C-T-7 can be lethal even in small doses;^[20] however, they provide no source for their claim and of the three known deaths (as of August 2007) of 2C-T-7 intoxicated individuals, all involved either uncommonly large insufflated doses or the concomitant ingestion of other stimulants such asephedrine and/orMDMA.

All of the three aforementioned known deaths of individuals under the influence of 2C-T-7 occurred in those known to be either intoxicated with other stimulants such asephedrine orMDMA (which are known to be potentially lethal in certain situations or at excessive doses)^[21] or after the individual insufflated an amount of 2C-T-7 much greater than necessary to induce the full range of effects typically sought after by users of the drug; for example, the reported 35 mg insufflated dose taken by the individual who died in the fall of 2000. This reported dose was characterized as "excessive" by the United States DEA.

The mechanism that produces the psychedelic effects of 2C-T-7 is most likely to result from action as a5-HT_2Aserotonin receptoragonist in the brain, a mechanism of action shared by most currently-known hallucinogenictryptamines andphenethylamines.^[29] 2C-T-7 has structural and pharmacodynamic properties similar to those of2C-T-2.^[1]

Thechemical synthesis of 2C-T-7 has been described.^[1][2]

2C-T-7 was first described in thescientific literature byMyron Stolaroff by 1990.^[5] It was developed byAlexander Shulgin andPeyton Jacob III.^[5][6][1] Subsequently, 2C-T-7 was described in greater detail by Shulgin and colleagues in 1991.^[6][1]

Up untilOperation Web Tryp and three deaths, two of which involved the use of other drugs in addition to 2C-T-7, and one which involved an excessive insufflated dose, 2C-T-7 was sold commercially in Dutch and Japanesesmartshops and online.^[3][4]

Around the year 2000, 2C-T-7 began to change from an obscure chemical to a drug used at parties and clubs in North America and Europe as it became available through a number of grey-market commercial vendors. This aroused the attention of the authorities, and many countries have since scheduled the chemical.

In Australia,2C-T-2 and 2C-T-7 are covered by the country'sanalogue drug laws.

As of October 31, 2016, 2C-T-7 is a controlled substance (Schedule III) in Canada.^[30]

As of October 2015 2C-T-7 is a controlled substance in China.^[31]

2C-T-7 is scheduled in the "government decree on substances, preparations and plants considered to be narcotic drugs".^[32]

2C-T-7 is scheduled in Germany. (BTMG)

The Netherlands was the first country in the world to ban 2C-T-7, after being sold in smartshops for a short period. After 2C-T-2 was first banned, 2C-T-7 quickly appeared on the market, but was soon banned as well. 2C-T-7 is a list I drug of theOpium Law.

Schedule I in Sweden.^[33] 2C-T-7 was first classified as "health hazard" under the actLagen om förbud mot vissa hälsofarliga varor (translatedAct on the Prohibition of Certain Goods Dangerous to Health) as of April 1, 1999, under SFS 1999:58^[34] that made it illegal to sell or possess.

In 1999,Alexander Shulgin was sent a copy of a letter from theBritish Home Office to several of its administrative associates that in effect placed all compounds listed inPiHKAL into Class A.^{[citation needed]}

On September 20, 2002, 2C-T-7 was classified as aSchedule I substance in the United States by an emergency ruling by theDEA. On March 18, 2004, the DEA published a Final Rule in the Federal Register permanently placing 2C-T-7 in Schedule I. (69 FR 12794)^[19][35][36]

As of April 2024, law enforcement have encountered 2C-T-7 in 16 states, with the highest number of encounters being in Florida. Purchases made over the internet are believed by the DEA to be the most common source by which users of the drug acquire it in the United States, and one laboratory manufacturing the drug was discovered by police inLas Vegas, Nevada.^[19]

• 2C (psychedelics)
• Aleph-7

• 2C-T-7 - Isomer Design
• 2C-T-7 - PsychonautWiki
• 2C-T-7 - Erowid
• 2C-T-7 - PiHKAL - Erowid
• 2C-T-7 - PiHKAL - Isomer Design
• 2C-T-7: A Mixed Bag of Psychedelic Tricks - Tripsitter

• Drugs not assigned an ATC code
• 5-HT2A agonists
• 5-HT2B agonists
• 2C (psychedelics)
• Alexander Shulgin
• Designer drugs
• PiHKAL
• Propylthio compounds
• Psychedelic phenethylamines
• TAAR1 agonists

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• Use mdy dates from June 2013
• Chemical pages without DrugBank identifier
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• Articles with unsourced statements from September 2016