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25B-NBF

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
25B-NBF
Clinical data
ATC code
  • (HCl): none
Legal status
Legal status
Identifiers
  • 2-(4-Bromo-2,5-dimethoxyphenyl)-N-(2-fluorobenzyl)ethanamine
CAS Number
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
3D model (JSmol)
  • (HCl): COC1=CC(CCNCC2=CC=CC=C2F)=C(OC)C=C1Br
  • (HCl): InChI=1S/C17H19BrFNO2.ClH/c1-21-16-10-14(18)17(22-2)9-12(16)7-8-20-11-13-5-3-4-6-15(13)19;/h3-6,9-10,20H,7-8,11H2,1-2H3;1H

25B-NBF (2C-B-NBF,NBF-2C-B) is a derivative of thephenethylaminehallucinogen2C-B, which acts as a highlypotentpartial agonist for thehuman5-HT2Areceptor.[1][2]

Legality

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Sweden

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The Riksdag added 25B-NBF toNarcotic Drugs Punishments Act underswedish schedule I ("substances, plant materials and fungi which normally do not have medical use") as of January 26, 2016, published byMedical Products Agency (MPA) in regulationHSLF-FS 2015:35 listed as25B-NBF, and2-(4-bromo-2,5-dimetoxifenyl)-N-(2-fluorobensyl)etanamin.[3]

United Kingdom

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This substance is aClass A drug in the United Kingdom as a result of theN-benzylphenethylamine catch-all clause in theMisuse of Drugs Act 1971.[4]

Analogues and derivatives

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Analogues and derivatives of2C-B:

25-N:

25-NB:

25-NM:

Substituted benzofurans:

N-(2C)-fentanyl:

Other:

References

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  1. ^Hansen M, Phonekeo K, Paine JS, Leth-Petersen S, Begtrup M, Bräuner-Osborne H, Kristensen JL (March 2014)."Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists".ACS Chemical Neuroscience.5 (3):243–9.doi:10.1021/cn400216u.PMC 3963123.PMID 24397362.
  2. ^Hansen M (2010-12-16).Design and Synthesis of Selective Serotonin Receptor Agonists for Positron Emission Tomography Imaging of the Brain (Ph.D. thesis). University of Copenhagen.doi:10.13140/RG.2.2.33671.14245.
  3. ^"Data"(PDF).lakemedelsverket.se. 2015. Archived fromthe original(PDF) on 2017-10-31. Retrieved2017-04-21.
  4. ^"The Misuse of Drugs Act 1971 (Ketamine etc.) (Amendment) Order 2014".UK Statutory Instruments 2014 No. 1106. www.legislation.gov.uk.
  5. ^"Explore N-(2C-B)-Fentanyl | PiHKAL · info".isomerdesign.com.
  6. ^"Explore N-(2C-FLY)-Fentanyl | PiHKAL · info".isomerdesign.com.
  7. ^Glennon, Richard A.; Bondarev, Mikhail L.; Khorana, Nantaka; Young, Richard; May, Jesse A.; Hellberg, Mark R.; McLaughlin, Marsha A.; Sharif, Najam A. (November 2004). "β-Oxygenated Analogues of the 5-HT2ASerotonin Receptor Agonist 1-(4-Bromo-2,5-dimethoxyphenyl)-2-aminopropane".Journal of Medicinal Chemistry.47 (24):6034–6041.doi:10.1021/jm040082s.ISSN 0022-2623.PMID 15537358.
  8. ^Beta-hydroxyphenylalkylamines and their use for treating glaucoma
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