Zhang Shuai defeated wildcardDayana Yastremska in the final, 3–6, 6–3, 6–4 to win the Singles title at the 2022 WTA Lyon Open.[1] It was her first title since2017. Yastremska was participating in her first event since fleeing her native country of Ukraine due to the2022 Russian invasion of Ukraine.[2]
Clara Tauson was the defending champion,[3] but chose not to participate.