Petronas Sprinta Racing withdrew from the category at the end of the 2021 season following the loss of their sponsor. The team continued under the same management and different sponsor in theMotoGP class.[44]
A new British team, run by former riderMichael Laverty, joined the championship with the aim of providing British riders with a stepping stone into the world championship starting from theBritish Talent Cup which was established in 2018. The team was sponsored by VisionTrack and the team took over the Honda bikes vacated by thePetronas SRT team.
Gresini Racing, who have competed from 2012 until 2021, left the championship to focus on their Moto2 and MotoGP teams.
Team MTA, which has competed in the CIV since 2017 and the CEV since 2019, made their return to the Moto3 World Championship with KTM. The team previously competed in the Moto3 World Championship from 2014 to 2016 as "Team Italia", using Mahindra bikes.[45]
Prüstel GP switched from actual KTM machines to CFMoto-rebranded KTM bikes.[46]
MT Helmets – MSi entered the championship as a new team.
Ryusei Yamanaka subsequently moved to the newly formed MT Helmets – MSi.[34]
Originally,Daniel Holgado was scheduled to make his debut withRed Bull KTM Tech3, teaming up withDeniz Öncü.[42] However, it was subsequently announced that Holgado will joinRed Bull KTM Ajo instead, where he would team up withJaume Masià.[40][41] Holgado has served as a replacement rider in 2021 and raced in both the 2021 CEV Moto3 Junior World Championship, where he won the championship, and 2021 Red Bull MotoGP Rookies Cup.Adrián Fernández took Holgado's entry at Tech3.
Mario Aji andTaiyo Furusato both made their full-time debuts with Honda Team Asia.[6] Aji has appeared as a wildcard rider in 2021 and raced in the 2021 CEV Moto3 Junior World Championship, while Furusato raced in the Asia Talent Cup. Both have also raced in the 2021 Red Bull MotoGP Rookies Cup.
Diogo Moreira made his full-time debut with MT Helmets – MSi.[35] He raced in both the 2021 Red Bull MotoGP Rookies Cup and 2021 CEV Moto3 Junior World Championship.
Gerard Riu replacedDavid Muñoz for the first seven rounds due to Muñoz being under the minimum age.[29]
Taiyo Furusato missed the Qatar and Indonesian rounds after having surgery due to a right ankle injury.[50] He was not replaced for both races.
John McPhee missed the Indonesian, Argentine, Americas, Portuguese, and Spanish rounds after sustaining two fractured vertebrae during training.[51][52] He was not replaced for the first two races, but was replaced byDavid Salvador for the next three races.[53][21]
Alberto Surra missed three races due to a right hand injury sustained in a FP3 crash during the Americas round. He was replaced bySyarifuddin Azman for the Portuguese and Spanish rounds, whileJosé Antonio Rueda replaced him for the French round[10][11] He returned during the Italian round, but suffered a fractured foot during FP3. He was replaced byMarcos Uriarte for the succeeding Catalan round.[12] Surra also missed the Japanese round after sustaining a fractured right hand in a FP3 crash during the previous Aragon round. He was replaced byKanta Hamada.[13]
Ayumu Sasaki missed the Catalan round after suffering an injury during the previous Italian round. He was replaced by David Salvador.[23]
Matteo Bertelle missed the Dutch round after suffering a left knee injury during the main race of the previous German round. He was replaced byLuca Lunetta.[38] Bertelle underwent a season-ending surgery during the summer break and was replaced byNicola Carraro for the rest of the season.[39]
Joel Kelso missed the British round after suffering an injury during the previous Dutch round. He was replaced byMarc García.[33]
Stefano Nepa missed the Valencian round after undergoing surgery to an injury suffered during the previous Malaysian round. He was replaced by David Salvador.[26]
The previously mentioned Finnish Grand Prix was planned to return to the calendar after a 39-year absence. The venue hosting the round would have been the newKymi Ring, instead of theTampere Circuit used in 1962 and 1963 or theImatra Circuit which hosted the round until 1982. The Grand Prix was included on both the 2020 and 2021 calendars, but both races were cancelled in response to theCOVID-19 pandemic. However, the race scheduled for July was cancelled in May due to incomplete homologation works and the risks associated with the geopolitical situation in the region.[70]
TheIndonesian Grand Prix returned to the calendar after a 24-year absence. The venue hosting the round was the newMandalika International Street Circuit, instead of theSentul International Circuit used in 1996 and 1997. The Grand Prix had been included in the 2021 calendar as a Reserve Grand Prix but was ultimately dropped before the end of the season.
TheBrazilian Grand Prix, which had previously been announced to return in 2022, was not included in the provisional calendar released on 7 October 2021.[71][54]
TheAustrian Grand Prix used a new layout of theRed Bull Ring, wherein a chicane was added to the previous fast slight-left hander of turn 2.[72] This was done to improve the overall safety of the track by greatly reducing the speed the riders take the turn. The final configuration was chosen among 15 proposals, with the track being 30 meters longer than the previous configurations.[73]
^abThis is the team name entered in the championship. Other team names used during the season areGaviota GasGas Aspar Team (rounds 1–2, 4, 6–7, 12, 14, 17–19),Solunion GasGas Aspar Team (round 3),Valresa GasGas Aspar Team (round 5, 8–9, 20), andAutoSolar GasGas Aspar Team (round 13, 15–16).
^abFrom rounds 1–8, the team used the team nameBoé SKX.
^Guevara, who set the fastest time during qualifying, was penalized for irresponsible riding during the second qualifying session. He started the race from the back of the grid, but he is still credited with the pole position.Ayumu Sasaki was promoted to the pole position grid slot during the race.[74]