Rafael Nadal was the defending champion,[3] but lost in the third round toDenis Shapovalov. Despite Nadal’s early exit, Djokovic extended their streak, which started in 2004, to 18 consecutive years with either Nadal or himself in the Rome final.
The following are the seeded players. Seedings are based on ATP rankings as of 2 May 2022. Rankings and points before are as of 9 May 2022.
As a result of special ranking adjustment rules due to theCOVID-19 pandemic, players are defending the higher of (i) their points from the2021 tournament or (ii) the remaining 50% of their points from the2020 tournament. Those points were not mandatory and are included in the table below only if they counted towards the player's ranking as of May 9, 2022. Players who are not defending points from the 2021 or 2020 tournaments will instead have their 19th best result replaced by their points from the 2022 tournament.
† This column shows either (a) the higher of the player's points from the 2021 tournament or 50% of his points from the 2020 tournament, or (b) his 19th best result (shown in brackets). Only ranking points counting towards the player's ranking as of May 9, 2022, are reflected in the column.