Leylah Fernandez defeatedViktorija Golubic in the final, 6–1, 6–4 to win the singles tennis title at the 2021 Monterrey Open.[1] Fernandez did not drop a set en route to her firstWTA Tour singles title.
Elina Svitolina was the reigning champion, but decided not to participate.[2]
Bold denotes the mandatory tournaments (WTA 1000) † –Tournaments are affected by theCOVID-19 pandemic * –Tournaments are introduced due to the impact of the COVID-19 pandemic