April 3–6, vs.Pittsburgh
In his Red Sox debut,Chris Sale struck out seven Pirates batters in his 7 shut-out innings. He received no run support until a three-run walk-off shot bySandy León in the 12th inning. Game three of the series was postponed and rescheduled for April 13.
Red Sox won the series 2–0 (8–3 runs)
April 7–10, inDetroit
In the series opener,Steven Wright gave up four runs in 62⁄3 innings. Down by four runs going into the eighth, the Red Sox put a five spot on the board, including a three-run shot byPablo Sandoval, only to have the bullpen give up two more runs to win it for the Tigers. In game two, Boston took an early 1–0 lead, but that's all they would get. Detroit scored four times againstEduardo Rodríguez and dropped two games in a row. With several players already down with the flu,Andrew Benintendi threw up during the sixth inning in the outfield but could finish the game.Rick Porcello gave up eleven hits but the Tigers could only push four players across the plate. In late game heroics, Boston scored four times to take the lead in the eighth.Craig Kimbrel gave up one run but eventually closed the game.Chris Sale went 72⁄3 innings, striking out 10 Tigers and allowing only two runs in the final game of the series, but that was enough for Detroit. Boston only scored once on a bases loaded, nobody out situation againstJustin Verlander in the second inning.
Red Sox lost the series 1–3 (14–17 runs)
April 11–12, vs.Baltimore
Drew Pomeranz went 6 innings of one-run ball in his season debut. Boston up by one run, scored three runs each in the seventh and eighth inning to put the game out of reach. In the second game of the odd two-game series against a division rival,Steven Wright was pulled after 11⁄3 innings, giving up 8 runs on as many hits. The bullpen allowed four more runs over the course of the game. A rally in the middle innings, where Boston scored 5 runs in three consecutive innings, fell way short.
Red Sox tied the series 1—1 (13–13 runs)
April 13, vs.Pittsburgh
In the makeup game from the opening series of the season,Eduardo Rodríguez allowed two first innings runs before settling in. Down by two runs coming into the eighth, the Pirates allowed three men to reach with one out, two via base on balls.Mookie Betts scored the go-ahead run from first on aHanley Ramírez double, but the close play at the plate was successfully challenged.Xander Bogaerts eventually drove in Hanley andCraig Kimbrel shut the door.
Red Sox won the series 1–0 (4–3 runs)
April 14–17, vs.Tampa Bay
Rick Porcello was shelled for 8 runs in4+1⁄3 innings, the most since April 19, 2015 vs. Baltimore. Down by 8 runs coming into the ninth, the Red Sox rallied for three, but that was all they could get. The doubles streak ofMitch Moreland ended after seven consecutive games.Chris Sale pitched another gem in his third start and won his first game of the season. He allowed just three hits and one run in seven innings, striking out 12 Rays batters. Moreland scored twice, on a solo shot in the second and aSandy León groundout, providing the only runs for Boston.Drew Pomeranz didn't make it through the fifth with five allowed runs, but the Red Sox out-hit the Rays 17–7.Pablo Sandoval ripped his team-leading fourth home run of the season onto the green monster. OnPatriots' Day, the Red Sox played their traditional 11 am game and quickly scored four runs in the first two innings, after Tampa Bay took a two-run lead in the first.Steven Wright gave up three runs, one of them earned, in six innings of work. The bullpen kept the Rays off the scoreboard andCraig Kimbrel struck out the side for his sixth save of the season.
Red Sox won the series 3–1 (18–19 runs)
April 18–20, inToronto
Brian Johnson outpitchedMarcus Stroman in a game where both teams connected for 27 hits. The Jays rallied for three runs in the ninth, but came one run short.Rick Porcello allowed three unearned runs but received no run-support and the Red Sox where shut out for the first time this season. In the rubber match,Chris Sale pitched another great game with 8 shut out innings, striking out 13. The save streak ofCraig Kimbrel ended on 25 on a lead-off home run byKendrys Morales, he eventually got the win, striking out five of the seven batters he faced.Mookie Betts drove in three in the tenth on a two-out double.
Red Sox won the series 2–1 (12–11 runs)
April 21–23, inBaltimore
The Red Sox where shutout for the second time in three games.Dustin Pedroia had to leave the game in the eighth, after a controversial slide with his raised cleats into second base byManny Machado. The Red Sox could not hold on to their 2–0 lead in the second game. Baltimore scored four times in the fourth andSteven Wright was pulled early.Eduardo Rodríguez pitched six shut out innings, allowing only one hit. He was aided by six runs and the first 5-for-5 performance byAndrew Benintendi of his career.Matt Barnes was ejected in the eighth on would be retaliation pitch against Machado, which hit his bat just inches away from his head. Barnes was eventually suspended for four games.
Red Sox lost the series 1–2 (8–8 runs)
April 26–27, vs.New York
The first game of the would-be three-game series was rained out and rescheduled for mid-July. In both gamesRick Porcello andChris Sale were given virtually no run support. Both allowed three runs, two earned. Sale struck out ten, but allowed 8 hits. Down just 0–1, Sale was back on the mound for the ninth, in which he gave up three straight hits, before being pulled with no outs recorded.
Red Sox lost the series 0–2 (1–6 runs)
April 28–30, vs.Chicago (NL)
The bats came to life with the reigning World Series champion in town. Boston scored five in the first offJake Arrieta. The Cubs rallied in the seventh but came up short. An early 3–0 lead was lost in the seventh on account of two errors in the same play by the Boston defense.Steven Wright started his last game of the season, he opted for season-ending surgery five days later. The Red Sox got to their former closerKoji Uehara in the eighth inning, with the game being tied at two, for four runs.Hanley Ramírez hit home runs in back-to-back games.Eduardo Rodríguez pitched another good game with one run allowed over six frames.Matt Barnes became the team's leader in pitcher wins with 3.
Red Sox won the series 2–1 (15–13 runs)

Composite line score April

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May 1–4, vs.Baltimore
Mookie Betts got plunked by a 95-mphDylan Bundy fastball in the first game of the series, but no warnings were issued and there weren't any further actions by either team.Rick Porcello gave up two runs in six innings. Baltimore scored three times in the 8th inning, aided by three Red Sox errors.Chris Sale threw behindManny Machado in the first inning and both benches were warned. Orioles relieverDonnie Hart threw a pitch atAndrew Benintendi's head but was not ejected nor disciplined for his action. Sale picked up the win, allowing only three hits in 8 innings. He struck out 11.Kevin Gausman was ejected in the second inning of game three, in which he hitXander Bogaerts with a 77-mph curveball. Later in the game,Adam Jones was ejected for arguing balls and strikes with homeplate umpireSam Holbrook.Drew Pomeranz became the first Red Sox starter with three wins in his 51⁄3 innings of work. The bullpen pitched a shutout andCraig Kimbrel picked up his tenth save of the season, striking out the side on 12 pitches. In the final game of the series, emotions cooled down and there were no further retaliations.Kyle Kendrick, in his first start for Boston, surrendered six runs in the loss. Baltimore connected for 17 hits.
Red Sox tied the series 2–2 (14–17 runs)

May 5–7, atMinneapolis
Matt Barnes gave up a walk-off home run to former AL MVPJoe Mauer, after the Red Sox rallied for two runs in the ninth to tie the game.Eduardo Rodríguez pitched six innings, giving up three runs on seven hits. The bats came alive in the second game of the series, scoring eight runs in the second inning. The bases were empty with two outs beforeChris Young started a rally with a solo home run. Nine batters reached base, eight of them via the hit and one of them on an error. Boston put three more runs on the board, including another home run by Young and bySandy León.Rick Porcello went seven innings of one-run ball. In the rubber match, finallyChris Sale received decent run support. Boston tagged the AL ERA leader, with 0.66,Ervin Santana for three runs in the first inning, aDustin Pedroia solo home run and an absolute blast byAndrew Benintendi withXander Bogaerts on first, which left the ballpark. After Boston extended the lead to four, Sale struggled in the fifth and the Twins tied up the game, only to give up a two-run home run toSandy León which barely left the park. Up by three in the eighth,Matt Barnes gave up a home run and could not make an out. LeftyRobby Scott got the out against the lefty batter but a run scored on the sacrifice fly. With the tying run on third and only one out,Craig Kimbrel came in in a high-leverage situation and struck out both batters he faced. In a 39-minute top of the ninth, seven consecutive players reached base safely with one out, beforeDeven Marrero grounded out. The inning was extended on a fielding error. Four more batters reached base safely, including three consecutive walks.Chris Young, the 15th batter of the inning, became the third out. Except for Marrero, every hitter in the line-up reached base safely; ten runs came across the plate to score. Santana allowed six runs in the game, all of them earned. He allowed only three runs in his previous six starts combined. Sale extended his 10+ strikeout streak to six.
Red Sox won the series 2–1 (32–12 runs)

May 9–11, atMilwaukee
The Brewers taggedDrew Pomeranz for six runs in four innings in the loss. Boston narrowed the gap to two runs in the fifth butHeath Hembree allowed three more runs in the sixth.Kyle Kendrick also allowed six runs in his start, a hole too deep for the offense to climb out of. Both teams collected 49 hits in the first two games combined. Coming into the game with a career ERA of 5.26 in day games, as opposed to his 3.36 ERA in night games,Eduardo Rodríguez pitched a three-hit, one-run game over six frames. He was pinch hit for in the seventh. Boston left the go-ahead run stranded at third with nobody out in the top of eighth.Craig Kimbrel was again summoned from the bullpen in a non-save situation, with the go-ahead run at first and one out in the bottom of the eighth. He struck outEric Thames, allowed an infield hit and the runner from second advanced to third on a wild pitch. Kimbrel ended the threat with another strikeout. In the top of the ninth,Christian Vázquez walked andDeven Marrero reached on an error.Mookie Betts put three runs on the board with his fifth home run of the season. Kimbrel struck out the side on a total of nine pitches to secure the win—it was the thirdimmaculate inning in Red Sox franchise history.^[12][13]
Red Sox lost the series 1–2 (15–19 runs)

This sectionneeds expansion. You can help byadding missing information.(August 2019)

May 12–14, vs.Tampa Bay
Red Sox lost the series 1–2 (12–19 runs)

May 16–17, atSt. Louis
Red Sox won the series 2–0 (11–7 runs)

May 18–20, atOakland
Red Sox lost the series 1–3 (20–22 runs)

May 23–25, vs.Texas
Red Sox won the series 3–0 (26–12 runs)

May 26–28, vs.Seattle
Red Sox won the series 2–1 (9–5 runs)

May 29–31, atChicago
Red Sox won the series 2–1 (21–13 runs)

This sectionneeds expansion. You can help byadding missing information.(August 2019)

August 3–August 6, vs.Chicago White Sox

August 8–August 9, atTampa Bay Rays

On August 9, the Red Sox defeated the Rays, 8–2, to extend their winning streak to eight games. In the fifth inning,Rick Porcello struck out the side on nine pitches; it was the fourthimmaculate inning in franchise history and second of the season, following one byCraig Kimbrel on May 11.^[13][14]

August 11–August 13, atNew York Yankees

August 14, vs.Cleveland Indians

August 15–August 16, vs.St. Louis Cardinals

August 18–August 20, vs.New York Yankees

August 21–August 24, atCleveland Indians

August 25–August 27, vs.Baltimore Orioles
This three-game series was played on the inauguralPlayers Weekend, when MLB players are allowed and encouraged to put nicknames on the back of their uniforms. For the opening game, the nicknames used by Boston's starting lineup were as follows:^[15][16]

The August 25 game, a 16–3 win by Baltimore, was notable for the Red Sox making an illegal player re-entry late in the game, which went undetected at the time. With the Orioles leading by 13 runs, position playerMitch Moreland pitched the ninth inning for Boston, withHanley Ramírez entering the game to play first base, resulting in loss of thedesignated hitter. Ramírez should have takenChris Young's position in the batting order (seventh). However, with one out in the bottom of the ninth inning, Young batted in his (former) seventh position in the order, which is an illegal player re-entry. Young hit a single, and the game ended three batters later, with Young's hit having no bearing on the outcome of the game. The illegal player re-entry appears to be unique in MLB history.^[17]

†Minimum 3.1plate appearances per team games played
   AVG qualified batters: Benintendi, Betts, Bogaerts, Bradley, Moreland, Ramirez
‡Minimum 1inning pitched per team games played
   ERA & WHIP qualified pitchers: Pomeranz, Porcello, Sale