| Date | Time | Opponent | Site | TV | Result | Attendance | Source |
|---|
| September 1 | 12:00 pm | East Carolina | | ESPN | W 40–3 | 28,011 | [1] |
| September 13 | 12:00 pm | atWest Virginia* | | ESPN Plus | W 15–13 | 51,189 | |
| September 20 | 7:00 pm | Temple* | - Nippert Stadium
- Cincinnati, OH
| | W 30–243OT | 30,405 | |
| September 27 | 2:00 pm | atMiami (OH)* | | | L 42–37 | 27,512 | |
| October 4 | 7:00 pm | Southern Miss | - Nippert Stadium
- Cincinnati, OH
| | L 20–22 | 24,522 | [2] |
| October 11 | 4:00 pm | atUAB | | | L 14–31 | 17,072 | [3] |
| October 25 | 3:00 pm | Army | - Nippert Stadium
- Cincinnati, OH
| ESPN Plus | W 33–29 | 22,025 | |
| October 31 | 7:30 pm | atSouth Florida | | ESPN2 | L 17–24 | 28,616 | |
| November 8 | 2:00 pm | Rhode Island* | - Nippert Stadium
- Cincinnati, OH
| | W 31–24 | 14,006 | |
| November 15 | 3:00 pm | at No. 10TCU | | | L 10–43 | 42,161 | |
| November 22 | 2:00 pm | atMemphis | | | L 16–21 | 42,884 | |
| November 28 | 11:00 am | Louisville | | ESPN2 | L 40–43 | 11,993 | |
- *Non-conference game
Homecoming- Rankings fromAP Poll released prior to the game
- All times are inEastern time
|