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20α-Dihydrotrengestone

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
20α-Dihydrotrengestone
Clinical data
Other names20α-DHTG; 20α-Hydroxytrengestone; 6-Chloro-20(S)-hydroxy-9β,10α-pregna-1,4,6-trien-3-one
Drug classProgestin;Progestogen
Pharmacokinetic data
Eliminationhalf-life8–14 hours[1]
Identifiers
CAS Number
Chemical and physical data
FormulaC21H26ClO2
Molar mass345.89 g·mol−1
3D model (JSmol)
  • O([H])[C@@](C)[C@]([H])1CC[C@]([H])2[C@@]([H])3C=C(Cl)C4=CC(C=C[C@@]4(C)[C@]3([H])CC[C@@]21C)=O
  • InChI=1S/C21H26ClO2/c1-12(23)15-4-5-16-14-11-19(22)18-10-13(24)6-8-21(18,3)17(14)7-9-20(15,16)2/h6,8,10-11,14-17,23H,4-5,7,9H2,1-3H3/t14-,15+,16-,17+,20+,21-/m0/s1
  • Key:YOKUOTGYGGEOMR-OAYGGAORSA-N

20α-Dihydrotrengestone (20α-DHTG), also known as20α-hydroxytrengestone, as well as6-chloro-20(S)-hydroxy-9β,10α-pregna-1,4,6-trien-3-one, is aprogestin and the majoractive metabolite oftrengestone.[1][2] It appears that trengestone is aprodrug of 20α-DHTG, as it is largelytransformed into thismetabolite when givenorally in humans.[2][1] 20α-DHTG haspotentprogestogenic activity similarly to trengestone.[1]

See also

[edit]

References

[edit]
  1. ^abcdDixon R, Tormey P, Darragh A (March 1975). "Disposition of the retro-steroid progestogen, 6-chloro-9beta, 10alpha-pregna-1,4,6-triene-3,20-dione (Ro 4-8347), in man".Contraception.11 (3):339–46.doi:10.1016/0010-7824(75)90042-6.PMID 1116370.
  2. ^abBreuer H, Kime DE, Knuppen R (September 1973). "Metabolism of 6-chloro-9 beta, 10 alpha-pregna-1,4,6-triene-3,20-dione in rat, rabbit, monkey and man".Acta Endocrinol.74 (1):127–43.doi:10.1530/acta.0.0740127.PMID 4202495.


PRTooltip Progesterone receptor
Agonists
Mixed
(SPRMsTooltip Selective progesterone receptor modulators)
Antagonists
mPRTooltip Membrane progesterone receptor
(PAQRTooltip Progestin and adipoQ receptor)
Agonists
Antagonists

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