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| Names | |
|---|---|
| Preferred IUPAC name Quinolin-2(1H)-one | |
Other names
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| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.000.382 |
| EC Number |
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| KEGG | |
| UNII | |
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| Properties | |
| C9H7NO | |
| Molar mass | 145.161 g·mol−1 |
| Appearance | solid |
| Melting point | 199.5 °C (391.1 °F; 472.6 K) |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
2-Quinolone is anorganic compound related structurally toquinoline. It is the majoritytautomer in equilibrium with2-quinolinol. The compound can be classified as a cyclicamide, and as such is used as an isostere for peptides and other pharmaceutically inspired targets.[1][2] The 4-methyl-2-quinolone can be prepared by dehydration ofacetoacetanilide.[3]
The isomer4-quinolone is the parent of a large class of antibiotics calledquinolone antibiotics. A prominent example isciprofloxacin, abroad spectrum antibiotic commonly used for treatment of various infections such asurinary tract infections (UTIs),typhoid,meningitis,gonorrhoea,syphilis,[4] andskin infections.[5]
Media related to2-Quinolone at Wikimedia Commons