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2,8-Dihydroxyhexahydrochrysene

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
2,8-Dihydroxyhexahydrochrysene
Clinical data
ATC code
  • None
Identifiers
CAS Number
PubChemCID
ChemSpider
Chemical and physical data
FormulaC18H18O2
Molar mass266.340 g·mol−1
3D model (JSmol)
  • OC1C=CC2=C(C=1)CCC3C2CCC4C3=CC=C(O)C=4
  • InChI=1S/C18H18O2/c19-13-3-7-15-11(9-13)1-5-17-16-8-4-14(20)10-12(16)2-6-18(15)17/h3-4,7-10,17-20H,1-2,5-6H2
  • Key:WKSBLYZBEPGLTB-UHFFFAOYSA-N

2,8-Dihydroxyhexahydrochrysene (2,8-DHHHC) is asynthetic,nonsteroidal weakestrogen with approximately 1/2,000th the estrogenic potency of the structurally-related estrogendiethylstilbestrol.[1][2][3] It is said to be intermediate instructure betweenestradiol andhexestrol, but conversely to both of them, it is drastically less potent in comparison.[3]

See also

[edit]

References

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  1. ^Maximov PY, McDaniel RE, Jordan VC (23 July 2013).Tamoxifen: Pioneering Medicine in Breast Cancer. Springer Science & Business Media. pp. 4–.ISBN 978-3-0348-0664-0.
  2. ^Jordan VC (1986).Estrogen/antiestrogen Action and Breast Cancer Therapy. Univ of Wisconsin Press. pp. 22–.ISBN 978-0-299-10480-1.
  3. ^abWilds AL, Sutton RE (1951). "Cyclic Analogs of Hexestrol in the Chrysene Series".The Journal of Organic Chemistry.16 (9):1371–1379.doi:10.1021/jo50003a006.ISSN 0022-3263.
ERTooltip Estrogen receptor
Agonists
Mixed
(SERMsTooltip Selective estrogen receptor modulators)
Antagonists
GPERTooltip G protein-coupled estrogen receptor
Agonists
Antagonists
Unknown


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