2,2,2-Trichloroethanol is thechemical compound withformulaCl3C−CH2OH. Itsmolecule can be described as that ofethanol, with the threehydrogen atoms at position 2 (themethyl group) replaced bychlorine atoms. It is a clear flammable liquid at room temperature, colorless when pure but often with a light yellow color.[1][2]
The pharmacological effects of this compound in humans are similar to those of itsprodrugchloral hydrate, and ofchlorobutanol. Historically, it has been used as a sedative hypnotic.[3] The hypnotic drugtriclofos (2,2,2-trichloroethyl phosphate) is metabolizedin vivo to 2,2,2-trichloroethanol. Chronic exposure may result in kidney and liver damage.[4]
^S. Budavari; M. O'Neil; Ann Smith; P. Heckelman; J. Obenchain (15 March 1996).The Merck Index (12th print ed.). Taylor & Francis.ISBN978-0-911910-12-4.
^Ladner, Carol (March 2004). "Visible fluorescent detection of proteins in polyacrylamide gels without staining".Analytical Biochemistry.326 (1):13–20.doi:10.1016/j.ab.2003.10.047.PMID14769330.
