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| Pharmacokinetic data | |
|---|---|
| Bioavailability | High[medical citation needed] |
| Eliminationhalf-life | Slow[medical citation needed] |
| Identifiers | |
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| CAS Number | |
| PubChemCID | |
| ChemSpider | |
| Chemical and physical data | |
| Formula | C21H25NO |
| Molar mass | 307.437 g·mol−1 |
| 3D model (JSmol) | |
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2β-Propanoyl-3β-(2-naphthyl)-tropane orWF-23 (Wake Forest-23, named after the university where it was first created) is acocaineanalogue. It is several hundred times more potent than cocaine at being aserotonin-norepinephrine-dopamine reuptake inhibitor.[1]
As can be seen onPubMed, these acyl substituted phenyltropanes are highly potentMAT inhibitors and also have a very longhalf-life, spanning perhaps at least a few days;[2][3] as the half-life of the dopamine transporter in rats was found to be 2–3 days under normal conditions (with agonists, antagonists, and transporter inhibitors altering the half-life),[4] it may be that WF-23 largely or mostly binds to its transporters until they are degraded.
WF-23 is made from methyl-ferruginine i.e.PC10080982 [152668-77-4].
