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1V-LSD

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
1V-LSD
Clinical data
Other names1-Valeryl-LSD; 1-Valeroyl-LSD; 1-Pentanoyl-LSD; Valerie; 1-Valeryl-N,N-diethyllysergamide
Routes of
administration
Oral
Drug classSerotonergic psychedelic;Hallucinogen
Legal status
Legal status
Identifiers
  • (6aR,9R)-N,N-Diethyl-7-methyl-4-pentanoyl-4,,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
CAS Number
PubChemCID
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC25H33N3O2
Molar mass407.558 g·mol−1
3D model (JSmol)
  • CCN(CC)C(=O)[C@@H]5C=C2[C@@H](Cc3cn(C(=O)CCCC)c4cccc2c34)N(C)C5
  • InChI=1S/C25H33N3O2/c1-5-8-12-23(29)28-16-17-14-22-20(19-10-9-11-21(28)24(17)19)13-18(15-26(22)4)25(30)27(6-2)7-3/h9-11,13,16,18,22H,5-8,12,14-15H2,1-4H3/t18-,22-/m1/s1
  • Key:GIIBVGJWUZNECE-XMSQKQJNSA-N

1V-LSD, also known as1-valeryl-LSD or by the nicknameValerie, is apsychedelic drug of thelysergamide family related tolysergic acid diethylamide (LSD).[1] It is ananalogue of LSD and is thought to act as aprodrug of LSD.[2]

1V-LSD has been sold online until an amendment to the GermanNpSG was enforced in 2022 which controls1P-LSD and now1cP-LSD, 1V-LSD and several otherlysergamides.[1][additional citation(s) needed]

Use and effects

[edit]
See also:LSD § Uses, andLSD § Effects

1V-LSD has been sold in the form ofblotter containing 150 μg per tab.[1] Its effects are said to be comparable to 100 to 120 μg1P-LSD or1cP-LSD, but with a longerduration.[1] On the other hand, other sources report that 1V-LSD has a shorter duration thanLSD of 6 to 8 hours.[3][4]

Interactions

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See also:Psychedelic drug § Interactions, andTrip killer § Serotonergic psychedelic antidotes

Pharmacology

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Pharmacodynamics

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As demonstrated with otherN-acylated derivatives of LSD, 1V-LSD is believed to serve as aprodrug for LSD but may also act directly as a weakpartial agonist at theserotonin5-HT2A receptor.[2]

Ahead-twitch response assay in mice found that 1V-LSD has a similar potency to1P-LSD and1cP-LSD, with behavioral effects also closely resembling thesestructural analogs.[5]

Chemistry

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Synthesis

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1V-LSD is the condensation product ofvaleric acid (pentanoic acid) and LSD, where the valeroyl group is substituted on the NH position of theindole moiety.[6]

Detection

[edit]

Ehrlich's reagent is used to identify the presence of an indolemoiety; the chemical backbone of the lysergamide andergoline molecules.[7] However, as with other N-acylated lysergamides, 1V-LSD reacts very slowly to Ehrlich reagent and may not give reliable results if the reagent isn't fresh.[8][9]

Analogues

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Related compounds include1B-LSD,1cP-LSD,1D-LSD,1P-LSD, andAL-LAD, among others.

Society and culture

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Legal status

[edit]
1v-LSD strip blotters.

Canada

[edit]

1V-LSD is not an explicitly nor implicitlycontrolled substance inCanada as of 2025.[10]

Germany

[edit]

An amendment to the NpSG banned the sale of 1V-LSD in Germany in September 2022. Due to a interpunctation error in the actualised NpSG, the ban never took effect.[11] The law was amended in March 2023, now banning 1V-LSD.

South Korea

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1V-LSD was placed under legal control in South Korea in July 2022 on a temporary but renewable basis.[12]

Sweden

[edit]

Since 2 March 2022, 1V-LSD has been under investigation in Sweden and may therefore soon become controlled.

United States

[edit]

1V-LSD is not an explicitlycontrolled substance in theUnited States.[13] However, it could be considered acontrolled substance under theFederal Analogue Act if intended for human consumption.[14]

See also

[edit]

References

[edit]
  1. ^abcd"1V-LSD".АИПСИН (in Russian). Retrieved1 January 2026.
  2. ^abBrandt SD, Kavanagh PV, Westphal F, Pulver B, Morton K, Stratford A, et al. (November 2021)."Return of the lysergamides. Part VII: Analytical and behavioural characterization of 1-valeroyl-d-lysergic acid diethylamide (1V-LSD)".Drug Testing and Analysis.14 (4):733–740.doi:10.1002/dta.3205.PMC 9191648.PMID 34837347.
  3. ^Niesporek T (17 August 2022).Der Hype um legales LSD in Deutschland: Wie das Verbot umgangen wird [The hype surrounding legal LSD in Germany: How the ban is circumvented] (in German).VICE auf Deutsch. Event occurs at 2:10–8:12, 20:05–20:41. Retrieved29 September 2025 – via YouTube.
  4. ^Niesporek T (17 August 2022)."Wir haben den Erfinder von legalem LSD getroffen" [We met the inventor of legal LSD].VICE. Archived fromthe original on 29 September 2025. Retrieved29 September 2025.
  5. ^Halberstadt AL, Chatha M, Klein AK, McCorvy JD, Meyer MR, Wagmann L, Stratford A, Brandt SD (August 2020)."Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD)".Neuropharmacology.172 107856.doi:10.1016/j.neuropharm.2019.107856.PMC 9191647.PMID 31756337.
  6. ^Umehara A, Ueda H, Tokuyama H (November 2016). "Condensation of Carboxylic Acids with Non-Nucleophilic N-Heterocycles and Anilides Using Boc2O".The Journal of Organic Chemistry.81 (22):11444–11453.doi:10.1021/acs.joc.6b02097.PMID 27767302.
  7. ^De Faubert Maunder MJ (August 1974). "A field test for hallucinogens: further improvements".The Journal of Pharmacy and Pharmacology.26 (8):637–8.doi:10.1111/j.2042-7158.1974.tb10677.x.PMID 4155730.S2CID 97915487.
  8. ^"REACTIONS 1V-LSD".PRO Test. 16 July 2021.
  9. ^"1V-LSD reaction with the ehrlich reagent".PRO Test. 16 July 2021.
  10. ^"Controlled Drugs and Substances Act".Department of Justice Canada. 5 December 2025. Retrieved20 January 2026.
  11. ^"Gesetzespanne: Gefährliche LSD-Derivate plötzlich legal".
  12. ^Kim Chan-hyuk, Regulator names 1V-LSD as narcotic drug temporarily.Korea Biomedical Review, 5 July 2022
  13. ^Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026)(PDF),United States: U.S.Department of Justice:Drug Enforcement Administration (DEA): Diversion Control Division, January 2026
  14. ^21 U.S. Code § 813 - Treatment of controlled substance analogues

External links

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