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| Routes of administration | oral |
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| Formula | C25H33N3O2 |
| Molar mass | 407.558 g·mol−1 |
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1V-LSD (1-valeryl-D-lysergic acid diethylamide), sometimes nicknamedValerie, is apsychotropic substance and aresearch chemical withpsychedelic effects.[1][2] 1V-LSD is an artificialderivative of naturallysergic acid, which occurs inergot alkaloids, as well as being ananalogue ofLSD.[3] 1V-LSD has been sold online until an amendment to the GermanNpSG was enforced in 2022 which controls1P-LSD and now1cP-LSD, 1V-LSD and several otherlysergamides.[4]
As demonstrated with other N-acylated derivatives of LSD, 1V-LSD is believed to serve as aprodrug for LSD but may also act as a weakpartial agonist at the5-HT2A receptor.[3]
AHead-twitch response assay in mice found that 1V-LSD has a similar potency to 1P-LSD and1cP-LSD, with behavioral effects also closely resembling thesestructural analogs.[5]
1V-LSD is the condensation product ofvaleric acid (pentanoic acid) and LSD, where the valeroyl group is substituted on the NH position of theindole moiety.[6]Ehrlich's reagent is used to identify the presence of an indolemoiety; the chemical backbone of the lysergamide andergoline molecules.[7] However, as with other N-acylated lysergamides, 1V-LSD reacts very slowly to Ehrlich reagent and may not give reliable results if the reagent isn't fresh.[8][9]
1V-LSD is not a controlled substance inNorth America (United States and Canada), unless sold for human consumption in theUS.[10]
Since March 2nd 2022, 1V-LSD has been under investigation in Sweden and may therefore soon become controlled.
1V-LSD was placed under legal control in South Korea in July 2022 on a temporary but renewable basis.[11]
An amendment to the NpSG banned the sale of 1V-LSD in Germany in September 2022. Due to a interpunctation error in the actualised NpSG, the ban never took effect.[12] The law was amended in March 2023, now banning 1V-LSD.
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