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1P-BOL-148

From Wikipedia, the free encyclopedia

Pharmaceutical compound
1P-BOL-148
Clinical data
Other names1-Propionyl-2-bromo-LSD; SYN-L-017
Identifiers
  • (6aR,9R)-5-bromo-N,N-diethyl-7-methyl-4-propanoyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide
PubChemCID
Chemical and physical data
FormulaC23H28BrN3O2
Molar mass458.400 g·mol−1
3D model (JSmol)
  • CCC(=O)N1C2=CC=CC3=C2C(=C1Br)C[C@@H]4C3=C[C@H](CN4C)C(=O)N(CC)CC
  • InChI=1S/C23H28BrN3O2/c1-5-20(28)27-18-10-8-9-15-16-11-14(23(29)26(6-2)7-3)13-25(4)19(16)12-17(21(15)18)22(27)24/h8-11,14,19H,5-7,12-13H2,1-4H3/t14-,19-/m1/s1
  • Key:PLXWJCJZSCKGNW-AUUYWEPGSA-N

1P-BOL-148, also known as1-propionyl-2-bromo-LSD or asSYN-L-017, is ananalogue ofLSD which acts as aprodrug for2-bromo-LSD (BOL-148). It does not havehallucinogenic effects, but is claimed to be potentially useful for the treatment ofcluster headaches,[1] and as anantidepressant.[2]

See also

[edit]

References

[edit]
  1. ^WO 2024/028495, Stratford A, Williamson JP, "Prodrugs of Substituted Ergolines", published 8 February 2024, assigned to Synex Holdings BV 
  2. ^WO 2023/141636, Duncton M, Clark S, "Prodrugs of 2-Bromo-LSD (2-Bromolysergic acid diethylamide)", published 27 July 2023, assigned to Terran Biosciences Inc. 
5-HT1
5-HT1A
5-HT1B
5-HT1D
5-HT1E
5-HT1F
5-HT2
5-HT2A
5-HT2B
5-HT2C
5-HT37
5-HT3
5-HT4
5-HT5A
5-HT6
5-HT7
Ergolines
(incl.lysergines)
Clavines
(6,8-dimethylergolines)
Lysergamides
(lysergic acid amides)
Ergopeptines
(peptide ergolines)
Partial ergolines
Related compounds
Natural sources
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