June 2 – TheSeattle Mariners use the number-one overall pick of the draft to selectKen Griffey Jr., signaling a turnaround in their fortunes as an organization.
July 14 –Tim Raines caps a 3-for-3 performance in theAll-Star Game with a two-run triple in the top of the 13th inning, giving theNational League a 2–0 victory over theAmerican League. Raines is selected the MVP.
July 18 – New York Yankees first basemanDon Mattingly homers in his record-tying eighth straight game, in a 7–2 loss to the Texas Rangers. He ties the record set byDale Long in 1956.
August 11 –Mark McGwire of theOakland Athletics breaksAl Rosen's American League rookie record by hitting his 38th home run in an 8–2 loss to the Mariners.
August 30 – With knuckleball pitcherCharlie Hough on the mound,Texas Rangers catcherGeno Petralli ties a Major League record by committing sixpassed balls in a 7–0 loss to theDetroit Tigers atTiger Stadium. All seven runs are unearned and come as a result of the passed balls. Petralli will go on to commit 35 passed balls on the season, breakingJ. C. Martin's single-season record of 33 in 1965.
September 9 –Nolan Ryan strikes out 16 to pass 4,500 for his career as theHouston Astros beat theSan Francisco Giants 4–2. Ryan strikes out 12 of the final 13 batters and fansMike Aldrete to complete the seventh inning for his 4,500th strikeout.
September 18 –Darrell Evans hits his 30thhome run of the season, and becomes the first player to do so after the age of 40.
September 21 –Darryl Strawberry swipes his 30th base of the season to join the30–30 club. With teammateHoward Johnson already having joined, it marks the first time that two teammates achieve 30–30 seasons in the same year.
October 4 – TheDetroit Tigers defeat theToronto Blue Jays 1–0 to clinch theAmerican League East division title. The victory caps off a thrilling pennant race in which the Tigers overcame a 3.5 game deficit to the Blue Jays in the last two weeks of the season, including sweeping the Blue Jays atTiger Stadium in the final weekend, and finishing two games ahead of Toronto in the standings.
October 25 – In Game Seven of theWorld Series, starterFrank Viola and relieverJeff Reardon hold theSt. Louis Cardinals to six hits, as theMinnesota Twins win 4–2 for their second World Championship, and their first since moving to Minnesota and changing their name to the Twins. The franchise's first title came in1924 as the Washington Senators. Viola is named the Series MVP.