The1959 Oklahoma State Cowboys football team representedOklahoma State University–Stillwater as an independent during the1959 college football season. In their fifth season under head coachCliff Speegle, the Cowboys compiled a 6–4 record and outscored opponents by a combined total of 181 to 161.^[1][2]

On offense, the 1959 team averaged 18.1 points scored, 195.2 rushing yards, and 118.5 passing yards per game.^[3] On defense, the team allowed an average of 15.1 points scored, 195.2 rushing yards, and 83.1 passing yards per game^[4] The team's statistical leaders included Jim Dillard with 582 rushing yards, Dick Soergel with 1,100 passing yards, Bill Dodson with 286 receiving yards, and Tony Banfield with 66 points scored.^[5]

The team played its home games atLewis Field inStillwater, Oklahoma.^[6]

Date	Opponent	Site	Result	Attendance	Source
September 19	Cincinnati	Lewis Field Stillwater, OK	L 9–22	20,000
September 26	atArkansas	War Memorial Stadium Little Rock, AR	L 7–13	30,000	[7]
October 3	atKansas State	Memorial Stadium Manhattan, KS	W 27–21	8,500
October 10	Tulsa	Lewis Field Stillwater, OK (rivalry)	W 26–0	21,000
October 17	Houston	Lewis Field Stillwater, OK	W 19–12	13,000	[8]
October 24	Wichita	Lewis Field Stillwater, OK	W 34–14
October 31	atMarquette	Marquette Stadium Milwaukee, WI	W 18–12	15,300
November 7	Denver	Lewis Field Stillwater, OK	W 20–12	15,000	[9]
November 14	atKansas	Memorial Stadium Lawrence, KS	L 14–28	15,000
November 28	at No. 17Oklahoma	Oklahoma Memorial Stadium Norman, OK (Bedlam Series)	L 7–17	59,136
Homecoming Rankings fromAP Poll released prior to the game

The1960 NFL draft was held on November 30, 1959. The following Cowboys were selected.^[10]

• 1959 Big Seven Conference football season
• Oklahoma State Cowboys football seasons
• 1959 in sports in Oklahoma

• Articles with short description
• Short description matches Wikidata
• Use mdy dates from August 2023
• Pages using CFB schedule with named parameters