The1942 United States Senate election in Oklahoma took place on November 3, 1942. Incumbent Democratic SenatorJoshua B. Lee ran for re-election to a second consecutive term. After winning the Democratic primary against several strong opponents, Lee advanced to the general election, where he was originally set to face former Republican SenatorWilliam B. Pine. However, shortly after winning the Republican primary, Pine died; the state Republican Party tapped businessmanEdward H. Moore as its replacement nominee. In afavorable Republican environment, Moore defeated Lee by a wide margin to win his first and only term in the U.S. Senate.
After he won the Republican primary,William B. Pine died, leaving a vacancy on the Republican ticket.[4] The Republican Party selected wealthy businessmanEdward H. Moore as its replacement nominee.[5]