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| Names | |
|---|---|
| IUPAC name 3-Hydroxyestra-1,3,5(10)-triene-16,17-dione | |
| Systematic IUPAC name (3aS,3bR,9bS,11aS)-7-Hydroxy-11a-methyl-3a,3b,4,5,9b,10,11,11a-octahydro-1H-cyclopenta[a]phenanthrene-1,2(3H)-dione | |
| Other names 16-Oxoestrone; 16-Keto-E1; 16-Oxo-E1; NSC-60462 | |
| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChemSpider | |
| KEGG | |
| UNII | |
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| Properties | |
| C18H20O3 | |
| Molar mass | 284.355 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
16-Ketoestrone (16-keto-E1, or16-oxoestrone, or16-oxo-E1) is anendogenousestrogen related to16α-hydroxyestrone and16β-hydroxyestrone.[1][2][3] In contrast to 16α-hydroxyestrone and 16β-hydroxyestrone, but similarly to16-ketoestradiol, 16-ketoestrone is a very weak estrogen with less than 1/1000 theestrogenicpotency ofestrone in theuterus.[3] 16-Ketoestrone has been reported to act as aninhibitor of17β-hydroxysteroid dehydrogenases.[4] 16-Ketoestrone can be converted by16α-hydroxysteroid dehydrogenase intoestriol in the body.[1][5]
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