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11-Hydroxycannabinol

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(Redirected from11-OH-CBN)
Chemical compound
Pharmaceutical compound
11-Hydroxycannabinol
Identifiers
  • 9-(hydroxymethyl)-6,6-dimethyl-3-pentylbenzo[c]chromen-1-ol
CAS Number
PubChemCID
ChemSpider
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC21H26O3
Molar mass326.436 g·mol−1
3D model (JSmol)
  • CCCCCC1=CC(=C2C(=C1)OC(C3=C2C=C(C=C3)CO)(C)C)O
  • InChI=1S/C21H26O3/c1-4-5-6-7-14-11-18(23)20-16-10-15(13-22)8-9-17(16)21(2,3)24-19(20)12-14/h8-12,22-23H,4-7,13H2,1-3H3
  • Key:YDKZOUNVEIGJPO-UHFFFAOYSA-N

11-Hydroxycannabinol (11-OH-CBN) is the main active metabolite ofcannabinol (CBN), one of the active components ofcannabis,[1] and has also been isolated from cannabis itself.[2] It is more potent than CBN itself, acting as an agonist of CB1 with around the same potency asTHC, but is a weak antagonist at CB2.[3][4]

See also

[edit]

References

[edit]
  1. ^Yamamoto I, Kuzuoka K, Watanabe K, Narimatsu S, Yoshimura H (1988). "Metabolic formation and pharmacological effects of 11-hydroxycannabinol, an active metabolite of cannabinol.". In Chesher G, Consroe P, Musty R (eds.).Marihuana: an international research report. National Campaign Against Drug Abuse, monograph series No. 7. Canberra: Australian Government Printing Office. pp. 135–140.
  2. ^de A Leite J, de Oliveira MV, Conti R, de S Borges W, Rosa TR, Filgueiras PR, Lacerda V, Romão W, Neto ÁC (September 2018). "Extraction and isolation of cannabinoids from marijuana seizures and characterization by 1H NMR allied to chemometric tools".Science & Justice.58 (5):355–365.doi:10.1016/j.scijus.2018.06.005.PMID 30193661.S2CID 52175358.
  3. ^Yamamoto I, Watanabe K, Kuzuoka K, Narimatsu S, Yoshimura H (May 1987)."The pharmacological activity of cannabinol and its major metabolite, 11-hydroxycannabinol".Chemical & Pharmaceutical Bulletin.35 (5):2144–7.doi:10.1248/cpb.35.2144.PMID 3664823.
  4. ^Rhee MH, Vogel Z, Barg J, Bayewitch M, Levy R, Hanus L, et al. (September 1997). "Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase".Journal of Medicinal Chemistry.40 (20):3228–33.doi:10.1021/jm970126f.PMID 9379442.
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