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11β-Methyl-19-nortestosterone dodecylcarbonate

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
11β-Methyl-19-nortestosterone dodecylcarbonate
Clinical data
Other names11β-MNTDC; CDB-4754
Routes of
administration
By mouth,intramuscular injection
Drug classAndrogen;Anabolic steroid;Androgen ester;Progestogen
Identifiers
  • [(8R,9S,10R,11S,13S,14S,17S)-11,13-dimethyl-3-oxo-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl] dodecyl carbonate
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC32H52O4
Molar mass500.764 g·mol−1
3D model (JSmol)
  • CCCCCCCCCCCCOC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3[C@@H](C)C[C@]12C
  • InChI=1S/C32H52O4/c1-4-5-6-7-8-9-10-11-12-13-20-35-31(34)36-29-19-18-28-27-16-14-24-21-25(33)15-17-26(24)30(27)23(2)22-32(28,29)3/h21,23,26-30H,4-20,22H2,1-3H3/t23-,26-,27-,28-,29-,30+,32-/m0/s1
  • Key:JVTCGMMASZPYDR-UIRZMXPTSA-N

11β-Methyl-19-nortestosterone 17β-dodecylcarbonate (11β-MNTDC) (developmental code nameCDB-4754) is asynthetic andorally activeanabolic–androgenic steroid (AAS) and aderivative ofnandrolone (19-nortestosterone) which was developed by the Contraceptive Development Branch (CDB) of theNational Institute of Child Health and Human Development (NICHD) and has not been marketed for medical use at this time.[1][2][3][4] It is anandrogen ester – specifically, the C17βdodecylcarbonateester of11β-methyl-19-nortestosterone (11β-MNT) – and acts as aprodrug of 11β-MNT in the body.[1][2][3][4]

11β-MNTDC is under development as abirth control pill for men.[5][6][7] It has been described as the "sister compound" ofdimethandrolone undecanoate, which is also under development as a birth control pill for men.[7][5]

Because 11β-MNTDC is not5α-reduced, in contrast totestosterone, it may have less risk ofscalp hair loss.[8]

See also

[edit]

References

[edit]
  1. ^abAttardi BJ, Marck BT, Matsumoto AM, Koduri S, Hild SA (2011)."Long-term effects of dimethandrolone 17β-undecanoate and 11β-methyl-19-nortestosterone 17β-dodecylcarbonate on body composition, bone mineral density, serum gonadotropins, and androgenic/anabolic activity in castrated male rats".Journal of Andrology.32 (2):183–192.doi:10.2164/jandrol.110.010371.PMID 20798389.
  2. ^abAttardi BJ, Hild SA, Koduri S, Pham T, Pessaint L, Engbring J, et al. (October 2010)."The potent synthetic androgens, dimethandrolone (7α,11β-dimethyl-19-nortestosterone) and 11β-methyl-19-nortestosterone, do not require 5α-reduction to exert their maximal androgenic effects".The Journal of Steroid Biochemistry and Molecular Biology.122 (4):212–218.doi:10.1016/j.jsbmb.2010.06.009.PMC 2949447.PMID 20599615.
  3. ^abHild SA, Attardi BJ, Koduri S, Till BA, Reel JR (2010)."Effects of synthetic androgens on liver function using the rabbit as a model".Journal of Andrology.31 (5):472–481.doi:10.2164/jandrol.109.009365.PMC 2943539.PMID 20378929.
  4. ^abUS 7820642, Blye RP, Kim HK, "Nandrolone 17β-carbonates", issued 26 October 2010, assigned to U.S. Department of Health and Human Services 
  5. ^abThirumalai A, Page ST (January 2019). "Recent Developments in Male Contraception".Drugs.79 (1):11–20.doi:10.1007/s40265-018-1038-8.PMID 30588563.S2CID 56895132.
  6. ^"Second potential male birth control pill passes human safety tests".
  7. ^abYuen F, Thirumalai A, Pham C, Swerdloff RS, Anawalt BD, Liu PY, Amory JK, Bremner WJ, Dart C, Wu H, Hull L, Blithe DL, Long J, Wang C, Page ST (March 2020)."Daily Oral Administration of the Novel Androgen 11β-MNTDC Markedly Suppresses Serum Gonadotropins in Healthy Men".The Journal of Clinical Endocrinology and Metabolism.105 (3):e835 –e847.doi:10.1210/clinem/dgaa032.PMC 7049261.PMID 31976519.
  8. ^Shapiro LJ, Shapiro DB (2018).Low Anabolic Profile in Assessing a Patient's Overall Hair Loss. pp. 687–698.doi:10.1007/978-4-431-56547-5_72.ISBN 978-4-431-56545-1.
ARTooltip Androgen receptor
Agonists
SARMsTooltip Selective androgen receptor modulator
Antagonists
GPRC6A
Agonists
PRTooltip Progesterone receptor
Agonists
Mixed
(SPRMsTooltip Selective progesterone receptor modulators)
Antagonists
mPRTooltip Membrane progesterone receptor
(PAQRTooltip Progestin and adipoQ receptor)
Agonists
Antagonists
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