βk-2C-B was not included nor mentioned inAlexander Shulgin's bookPiHKAL (Phenethylamines I Have Known and Loved).[7] However, it subsequently emerged as a novelrecreationaldesigner drug and its properties and effects were reported.[1] βk-2C-B is usually takenorally, but may also be used by otherroutes.[1]Insufflation is said to be not well-tolerated.[1] The drug has been said to be used at doses of 150 to 1,000mg orally.[1] Itsonset is said to be 20 to 70minutes and itsduration is said to long at 10 to 40hours.[1] The effects of βk-2C-B have been said to includeeuphoria,psychedelic visuals,entactogenic effects, and sensory enhancement, among others.[1]
The interactions of βk-2C-B withmonoamine oxidase (MAO) enzymes have been studied.[8] Weak inhibition caused by βk-2C-B is evident at anIC50Tooltip half-maximal inhibitory concentration of 14,000nM forMAO-B whereas forMAO-A inhibition was undetectable.[8]
The thermal decomposition of βk-2C-B has been studied using a simulated 'meth pipe' scenario.[9] Twelve major pyrolysis products were found for the thermally-induced decomposition of βk-2C-B.[9]
Canada: βk-2C-B is a Schedule III controlled substance as of October 12, 2016.[11]
Germany: βk-2C-B is controlled under the New Psychoactive Substances Act (NpSG) as of November 26, 2016. Possession is illegal but not penalized.[citation needed]
Sweden: βk-2C-B was classified as a narcotic on April 5, 2019.[12]
Switzerland: βk-2C-B is a controlled substance specifically named under Verzeichnis E.,[13]
United Kingdom: βk-2C-B is illegal to produce, supply or import under the Psychoactive Substance Act as of May 26, 2016.[14]
United States: βk-2C-B is unscheduled in the U.S., but may be considered an analogue of 2C-B under the Federal Analogue Act, and thus a Schedule I drug.[citation needed]
^abcdePower JD, Kavanagh P, O'Brien J, Barry M, Twamley B, Talbot B, et al. (June 2015). "Test purchase, identification and synthesis of 2-amino-1-(4-bromo-2, 5-dimethoxyphenyl)ethan-1-one (bk-2C-B)".Drug Testing and Analysis.7 (6):512–518.doi:10.1002/dta.1699.PMID25078895.
^abcGlennon RA, Bondarev ML, Khorana N, Young R, May JA, Hellberg MR, McLaughlin MA, Sharif NA (November 2004). "Beta-oxygenated analogues of the 5-HT2A serotonin receptor agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane".J Med Chem.47 (24):6034–6041.doi:10.1021/jm040082s.PMID15537358.
^abWagmann L, Brandt SD, Stratford A, Maurer HH, Meyer MR (February 2019). "Interactions of phenethylamine-derived psychoactive substances of the 2C-series with human monoamine oxidases".Drug Testing and Analysis.11 (2):318–324.doi:10.1002/dta.2494.PMID30188017.S2CID52166076.
^Frison G, Odoardi S, Frasson S, Sciarrone R, Ortar G, Romolo FS, Strano Rossi S (July 2015). "Characterization of the designer drug bk-2C-B (2-amino-1-(bromo-dimethoxyphenyl)ethan-1-one) by gas chromatography/mass spectrometry without and with derivatization with 2,2,2-trichloroethyl chloroformate, liquid chromatography/high-resolution mass spectrometry, and nuclear magnetic resonance".Rapid Communications in Mass Spectrometry.29 (13):1196–1204.doi:10.1002/rcm.7211.PMID26395784.
^"Åtta nya ämnen klassas som narkotika" [Eight new substances are classified as narcotics].Folkhälsomyndigheten [The Swedish Public Health Agency] (in Swedish). 5 April 2019.På förslag av Folkhälsomyndigheten har regeringen beslutat att klassificera ytterligare åtta ämnen som narkotika från och med den 5 april 2019. [On a proposal from the Swedish Public Health Agency, the government has decided to classify eight more substances as narcotics as of 5 April 2019.]
