Ubiquitin-conjugating enzyme E2 C is aprotein that in humans is encoded by theUBE2Cgene.[5][6]
The modification of proteins withubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes ofenzymes:ubiquitin-activating enzymes, or E1s,ubiquitin-conjugating enzymes, or E2s, andubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitoticcyclins and forcell cycle progression. Multiplealternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.[6]
Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20".Genomics.76 (1–3):45–57.doi:10.1006/geno.2001.6584.PMID11549316.
Takahashi Y, Ishii Y, Nishida Y, et al. (2006). "Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH".Cancer Genet. Cytogenet.168 (1):30–5.doi:10.1016/j.cancergencyto.2005.12.011.PMID16772118.
