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TP-13

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
TP-13
Ball-and-stick model of the TP-13 molecule
Identifiers
  • 7-Cyclobutyl-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-phenyl-1,2,4-triazolo[4,3-b] pyridazine
CAS Number
PubChemCID
ChemSpider
UNII
Chemical and physical data
FormulaC19H19N7O
Molar mass361.409 g·mol−1
3D model (JSmol)
  • C5CCC5c3cc2nnc(-c4ccccc4)n2nc3OCc1ncnn1C
  • InChI=1S/C19H19N7O/c1-25-17(20-12-21-25)11-27-19-15(13-8-5-9-13)10-16-22-23-18(26(16)24-19)14-6-3-2-4-7-14/h2-4,6-7,10,12-13H,5,8-9,11H2,1H3
  • Key:VACJUKKURQMWHE-UHFFFAOYSA-N
  (verify)

TP-13 is ananxiolytic drug with a novel chemical structure, which is used in scientific research. It has similar effects tobenzodiazepine drugs, but is structurally distinct and so is classed as anonbenzodiazepine anxiolytic. It is a subtype-selectivepartial agonist atGABAA receptors, binding selectively to GABAA receptor complexes bearing α2 and α3 subunits.[1] It has modestanticonvulsant activity although less than that ofdiazepam,[2] and its main effect is likely to be selectiveanxiolytic action, as seen with other related α2/3-preferring agonists such asL-838,417.

References

[edit]
  1. ^McCabe C, Shaw D, Atack JR, Street LJ, Wafford KA, Dawson GR, et al. (February 2004). "Subtype-selective GABAergic drugs facilitate extinction of mouse operant behaviour".Neuropharmacology.46 (2):171–8.doi:10.1016/j.neuropharm.2003.09.004.PMID 14680756.S2CID 38218522.
  2. ^Fradley RL, Guscott MR, Bull S, Hallett DJ, Goodacre SC, Wafford KA, et al. (June 2007). "Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands".Journal of Psychopharmacology.21 (4):384–91.doi:10.1177/0269881106067255.PMID 17092983.S2CID 34355306.
5-HT1ARTooltip 5-HT1A receptoragonists
GABAARTooltip GABAA receptorPAMsTooltip positive allosteric modulators
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