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SIGLEC9

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

SIGLEC9

Identifiers

Aliases

SIGLEC9, CD329, CDw329, FOAP-9, OBBP-LIKE, siglec-9, sialic acid binding Ig like lectin 9

External IDs

OMIM:605640;MGI:1932475;HomoloGene:130669;GeneCards:SIGLEC9;OMA:SIGLEC9 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.41	Start	51,124,906bp^[1]
Band	19q13.41	End	51,136,651bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7 B3\|7	Start	43,300,494bp^[2]
Band	7 B3\|7	End	43,309,585bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

monocyte

granulocyte

blood

spleen

upper lobe of left lung

gonad

right adrenal cortex

appendix

right lung

left adrenal gland

Top expressed in

granulocyte

zygote

secondary oocyte

spleen

blood

embryo

embryo

right kidney

bone marrow

primary oocyte

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	carbohydrate binding protein binding
Cellular component	integral component of membrane plasma membrane integral component of plasma membrane membrane secretory granule membrane
Biological process	cell surface receptor signaling pathway cell adhesion regulation of immune response neutrophil degranulation
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


27180


83382

Ensembl


ENSG00000129450


ENSMUSG00000030474

UniProt


Q9Y336


Q91Y57

RefSeq (mRNA)


NM_001198558 NM_014441


NM_031181

RefSeq (protein)


NP_001185487 NP_055256


NP_112458

Location (UCSC)

Chr 19: 51.12 – 51.14 Mb

Chr 7: 43.3 – 43.31 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Sialic acid-binding Ig-like lectin 9 is aprotein that in humans is encoded by theSIGLEC9gene.^[5]^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000129450 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000030474 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Foussias G, Yousef GM, Diamandis EP (Aug 2000). "Identification and molecular characterization of a novel member of the siglec family (SIGLEC9)".Genomics.67 (2):171–8.doi:10.1006/geno.2000.6208.PMID 10903842.
^"Entrez Gene: SIGLEC9 sialic acid binding Ig-like lectin 9".

Yousef GM, Luo LY, Diamandis EP (2000). "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4".Anticancer Res.19 (4B):2843–52.PMID 10652563.
Angata T, Varki A (2000)."Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways".J. Biol. Chem.275 (29):22127–35.doi:10.1074/jbc.M002775200.PMID 10801860.
Zhang JQ, Nicoll G, Jones C, Crocker PR (2000)."Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes".J. Biol. Chem.275 (29):22121–6.doi:10.1074/jbc.M002788200.PMID 10801862.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003)."The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment".Genome Res.13 (10):2265–70.doi:10.1101/gr.1293003.PMC 403697.PMID 12975309.
Sonnenburg JL, Altheide TK, Varki A (2004)."A uniquely human consequence of domain-specific functional adaptation in a sialic acid-binding receptor".Glycobiology.14 (4):339–46.doi:10.1093/glycob/cwh039.PMID 14693915.
Grimwood J, Gordon LA, Olsen A, et al. (2004)."The DNA sequence and biology of human chromosome 19".Nature.428 (6982):529–35.Bibcode:2004Natur.428..529G.doi:10.1038/nature02399.PMID 15057824.
Ikehara Y, Ikehara SK, Paulson JC (2004)."Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9".J. Biol. Chem.279 (41):43117–25.doi:10.1074/jbc.M403538200.PMID 15292262.
Avril T, Floyd H, Lopez F, et al. (2005)."The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells".J. Immunol.173 (11):6841–9.doi:10.4049/jimmunol.173.11.6841.PMID 15557178.
von Gunten S, Yousefi S, Seitz M, et al. (2005)."Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment".Blood.106 (4):1423–31.doi:10.1182/blood-2004-10-4112.PMID 15827126.
Rapoport EM, Pazynina GV, Sablina MA, et al. (2006). "Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides".Biochemistry Mosc.71 (5):496–504.doi:10.1134/S0006297906050051.PMID 16732727.S2CID 11537303.
Biedermann B, Gil D, Bowen DT, Crocker PR (2007). "Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors".Leuk. Res.31 (2):211–20.doi:10.1016/j.leukres.2006.05.026.PMID 16828866.

Protein:lectins

Animal

C-type lectins	Asialoglycoprotein receptor KLRD1 Collectin Mannan-binding lectin Mannose receptor proteochondroitin sulfate Aggrecan Versican Brevican Neurocan
SIGLEC	Sialoadhesin CD22 CD33 Myelin-associated glycoprotein SIGLEC5 SIGLEC6 SIGLEC7 SIGLEC8 SIGLEC9 SIGLEC10 SIGLEC12
Other	Calnexin Calreticulin Galectin N-Acetylglucosamine receptor Selectin

Plant

v t e Proteins:clusters of differentiation (see alsolist of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 -CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 -CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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