ThePoliclinico of Milan (Italian:Policlinico di Milano), also known asOspedale Maggiore di Milano orCa' Granda Ospedale Maggiore Policlinico, is the public district general hospital inMilan. It is one of the oldest hospitals inItaly, founded byFrancesco I Sforza,Duke of Milan, in 1456.^[1] Today it is a modern hospital with 900 beds, with wards for adults, pregnant women and children. During the first COVID-19 breakout in March 2020, 300 of those beds were readapted for COVID-19 patients.^[2]

Policlinico of Milan
Geography
Location	via Francesco Sforza, 28,Lombardy,Milan,Italy
Coordinates	45°27′36″N9°11′33″E / 45.4600°N 9.1924°E /45.4600; 9.1924
Organisation
Care system	Public
Funding	Public hospital
Type	Teaching, District General
Affiliated university	University of Milan
Services
Emergency department	Yes
Beds	900
Helipad	No
History
Opened	April 1456
Links
Website	www.policlinico.mi.it

There are three emergency rooms for different categories of patients. The maternity ward (Mangiagalli Clinic) has the highest number of births inLombardy.^[3]

The Foundation is a scientific Institute for Research, Hospitalization and Health Care (IRCCS), which means that, alongside clinical activity, it promotes research programs with predominantly translational purposes. The programs are concerned with the rapid transfer of therapies from the laboratory to patients.

As of 2020:

• President: Marco Giachetti (appointment 2019–2023)^[4]
• General Director: Ezio Belleri^[5]
• Administrative Director: Fabio Agrò^[6]
• Medical Director: Laura Chiappa^[7]
• Scientific Director: Fabio Blandini

In 1456 theDuke of Milan,Francesco Sforza, founded theMagna Domus Hospitalis (Ca' Granda), a hospital dedicated toAnnunciata (a municipality of the province of Brescia, Northern Italy). He did so primarily to gain the affection of its people, who were followers of Milan'sVisconti family, even though the Duke was married toBianca Maria Visconti at the time.

Entering Milan victorious on 25 March 1450 (the day ofAnnunciation), the Duke decided to dedicate a charitable institution to Annunciata. It was then that the new foundation became theSpedale della Nunciata. Designed by the renowned architectFilarete and built by the engineerGuiniforte Solari (responsible for the courtyard of the Certosa di Pavia, a monastery complex in Lombardy, Northern Italy), the hospital formed part of the completion of the reform of hospitals started by the ArchbishopRampini in the years of theGolden Ambrosian Republic.

The cloisters' completion and ornamentation were carried out byGiovanni Antonio Amadeo, Solari's son-in-law and pupil. Although the hospital was founded for the poor, it was from the outset a hospital where people with some hope of recovery were treated. Chronic diseases were treated in hospitals outside the city. For this reason the Ospedale Maggiore has always been the centre of health information in the city.

At the beginning of the 20th century, it was decided that the hospital would be moved to a location beyond thecanal (where work had already been started on its expansion). This move coincided with the founding of thestate university, which took over the old buildings of theCa' Granda, where it remains today. The Ospedale Maggiore moved to a vast area between the streets of Francesco Sforza (the site of thecanal), Porta Romana, Lamarmora and Commenda.

The obstetrics and gynaecology department was the first to be inaugurated, byLuigi Mangiagalli (the first Chancellor of the university), and the department still bears his name.

When the hospital moved it was decided that a general hospital would be created in the area ofNiguarda (a neighbouring municipality, which had become part of Milan in 1923). This hospital was designed by Giò Ponti and inaugurated in 1932. It kept the name Ca' Granda, whilst the new general hospital took the name Ospedale Maggiore.

Further additions to the hospital institution included theSan Carlo Borromeo di Milano (also designed by Giò Ponti) and theSesto San Giovanni hospitals. The institution was later divided, giving autonomy to the different institutes, whilst others were founded independently and included later.

In 1909 the Adelina brothers and Marco De Marchi founded theAsilo per le madri povere legittime "Regina Elena" (Regina Elena Refuge for Poor Mothers), which remained an independent service until 1990. In 1957 it was converted into a specialist hospital and in 1968 it became the Regina Elena Institute of Obstetrics-Gynaecology and Paediatrics. From 1998 to 2004 the clinical Institutes of Faithful Improvement, Mangiagalli and Regina Elena were placed under the sameauthority.

In 2010 the name of the hospital was changed, reverting to the former Ca' Granda.

The university has hosted prominent medical doctors and experts including:^[1]

• Carlo Forlanini - inventor of artificialpneumothorax.
• Edoardo Porro - innovator of thecaesarean section.
• Baldo Rossi - pioneer ofemergency surgery.
• Luigi Mangiagalli - founder ofIstituto Ostetrico Ginecologico.
• Luigi Devoto - pioneer ofoccupational medicine.

The organisation's insignia used to bear the scene of the Annunciation and the Latin motto 'ave gratiae plena' ("hail, full of grace"). Later it was simplified to a picture of thedove of the Holy Spirit.

The heraldic representation, still the basis of the Foundation's current logo, is closely linked with the Visconti symbol of the flaming, radiant turtle-dove. Theolive branch in the bird'sbeak was added later. Until 1825 the Organisation had the duty of assisting children in need, who, considered as 'the hospital's children', took thesurname 'Colombo', meaning 'dove'.

The Niguarda, Sesto San Giovanni and San Carlo Borromeo hospitals also obtained insignias or sculptures reminiscent of the dedication.

The hospital has two banners of honour: one large banner, maintained in a museum collection, and a pair of smaller banners for use in ceremonies.

The need for a banner to display at ceremonies and funerals of benefactors arose in 1927, and inspiration was taken from the banner of theMunicipality of Milan, which has particularly solemn connotations. The front of the banner represents theAnnunciation. On the other side, thedove is embroidered, surrounded by the heraldic insignias of the hospital's main benefactors:Sforza,Macchi, Del Sesto,Paravicini, Ponti,Secco Comneno, the municipality of Milano,Pio II Piccolomini,Pio IV Medici di Marignano,Pio XI Ratti, CardinalsSaint Carlo Borromeo e Schuster, and theOrder of the Holy Sepulchre.

The project and its realisation were the responsibility of the Milanese architectGiò Ponti, who intended to add value to the banner using both materials and techniques. The metallic parts of the banner were created by the Ravasco firm, andAlfredo Ravasco, the company director, wanted to donate precious stones. Meanwhile, the Bartelli firm had completed the gold and silver embroidery on pure silk. The banner was inaugurated by Cardinal Ildefonso Schuster on 24 March 1935 (the first day of theFestival of Forgiveness) during a solemn function held inMilan's Duomo.

In 1938 a copy was made, in order to be able to transport it with ease with just two poles. The original was moved to a collection in 1942 and decorated with crystals by the Silvestri firm.

At the beginning of the 19th century, the Milanese Carlo Ingnazio Busca brought amummy in asarcophagus and a papyrus to Milan. Today, the mummy can be found atSforza Castle, while the papyrus is housed in the Historical Archive of the General Hospital. It is not open to public viewing, but is reproduced digitally withinfra-red reflectography thanks to an agreement with theUniversity of Milan'sInterdepartmental Centre of Infrared and Diagnostic Reflectography of Cultural Heritage, run by Professor Duilio Bertani.

The ancient Egyptian papyrus is calledLibro per uscire dal giorno ("Book to leave the day") and reproduces the famousBook of the Dead, a series of formulae aimed to facilitate the soul on its last journey beyond the western horizon toward the afterlife. The scroll, almost seven metres long, was produced inThebes for the scribe and designer Pthamose at the beginning of thenineteenth dynasty of Egypt (1305-1200 BC). It shows a complete text, full of drawings, and it mentions a series of formulae to activate several amulets, which is rare in similar papyri.

The heirs of the mummy had to decide what to do with thissouvenir, and, taking advice from Dr. Pessani of theCiceri-Agnesi Fatebenesorelle Hospital, they were persuaded to donate it to the institute's pharmacy (the mummy was in fact, at the time, considered to be a pharmacological remedy). The mummy then became part of theCivic Archaeological and Numismatic Collections atSforza Castle.

The Ospedale Maggiore General Hospital- Mangiagalli- Regina Elena Foundation, has two executive committees which are divided into separate departments.

Ospedale Maggiore General Hospital Committee

• Zonda Department: generalsurgery andtransplants
• Monteggia Department: surgery (head and neck)
• Sacco Department:radiology,gastroenterology,cardiology,lungs
• Granelli-Marcora Department:internal medicine,endocrinology,haematology
• Litta Department: the first to be built in the area beyond the Canal in 1895; it houses theAssociation of Italian Rescue Workers
• Frigerio Department (Lamarmora): group practice
• Beretta Neuro Department: brain surgery
• Ponti Department:neurology
• Guardia Department: A&E, endoscopy
• Guardia II Department:psychiatry
• Marangoni Department:immunohaematology,transfusions andtransplants
• Bosisio Department:pathology

The hospital hosts the following biological sample banks and centers:^[8]

The hospital hosts the Milano Cord Blood Bank,^[9] which has an inventory of 9,000umbilical cord blood acquired from donations, which is used for more than 500stem cell transplants in Italy and abroad.

The biobank^[10] contains about 200,000 samples of biological materials such as serum, cells, DNA and RNA. These samples are kept between -80 and 196 °C and used by about 23 research programmes.

Part of the Transfusional Center, the blood bank is concerned with identifying donors for rare blood groups, as well as coordinating and maintaining regional and national efforts with regards to obtaining units of rare blood groups for cases concerning complex pathologies.^[11]

Cell Factory "Franco Calori" is a GMP facility devoted to the production of cellular therapy products to be employed in experimental clinical protocols. It hosts research efforts mainly dedicated to the study of adult human stem cells, their potential and their differentiating capacity, and a GMP unit for cell manipulation authorized for production of products for advanced cell therapy.

It is a collaborative organ donation and transplant program between the 5 regions of Italy and an Autonomous Province.^[12] Founded in 1972, the NITp is historically the first Italian organization in the field of transplants. It caters toover 20 million inhabitants inLombardy,Liguria,Veneto,Friuli-Venezia Giulia,Marche andthe Autonomous Province of Trento. The network manages the following centers:

• 93 units providing donors;
• 38 transplantation units (15 for kidney, 3 for kidney-pancreas, 9 for liver, 6 for heart, 4 for lungs and one for intestine) in 16 Hospitals;
• 5 regional coordinators and one from the Autonomous Province of Trento (CRR);
• 1 Interregional Reference Center (CIR).

The Interregional Reference Center (CIR) of this network is located at the IRCCS Foundation Ca Granda Ospedale Maggiore Policlinico, Complex Transplant Coordination Operative Unit.

The main functions of CIR, which operates operating 24/7, are:

• managing waiting lists for patients awaiting transplantation;
• collecting reports from potential organ donors and the verification of suitability and security;
• allocating of organs;
• performing immunologic examinations for donor-recipient compatibility.

The Policlinico of Milan has been accredited by the National Transplant Center to perform Fecal Microbial Transplants (FMT).[1]

The hospital also hostsBank of Donated Human Milk, aBiobank for the cryoconservation of seminal fluid and muscle tissue, peripheral nerve, DNA and cell culture^[13] which exchange valuable biological samples with National and International Institutes both for diagnostic and scientific research purposes.

• University of Milan

• Official Website
• Cell Factory "Franco Calori"
• Nord Italia Transplant program (NITp)