Poliovirus receptor-related 2 (PVRL2), also known asnectin-2 andCD112 (formerlyherpesvirus entry mediator B,HVEB), is a humanplasma membraneglycoprotein.[5]
This gene encodes a single-pass type I membrane glycoprotein with twoIg-like C2-type domains and anIg-like V-type domain. This protein is one of the plasma membrane components ofadherens junctions. It also serves as an entry for certain mutant strains ofherpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[5]
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Lopez M, Aoubala M, Jordier F, et al. (1999). "The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule".Blood.92 (12):4602–11.doi:10.1182/blood.V92.12.4602.PMID9845526.
Freitas EM, Zhang WJ, Lalonde JP, et al. (1999). "Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1".DNA Seq.9 (2):89–100.doi:10.3109/10425179809086433.PMID10520737.
Freitas EM, Phan TC, Herbison CE, et al. (2002). "The poliovirus receptor related 2 (PRR2) and apolipoprotein E genes and coronary heart disease".Journal of Cardiovascular Risk.9 (1):59–65.doi:10.1097/00043798-200202000-00009.PMID11984219.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation".Nat. Biotechnol.22 (6):707–16.doi:10.1038/nbt971.PMID15146197.S2CID27764390.
Rosche B, Cepok S, Stei S, et al. (2004). "The role of the polio virus receptor and the herpesvirus entry mediator B genes for the development of MS".J. Neuroimmunol.156 (1–2):171–7.doi:10.1016/j.jneuroim.2004.07.001.PMID15465608.S2CID39448365.
