Disuse supersensitivity, alsopharmacological disuse supersensitivity orpharmacological denervation supersensitivity, is the increased sensitivity by apostsynaptic cell because of decreased input by incomingaxons, e.g., due to the exposure to anantagonistdrug.[1][2]
Jaffe and Sharpless pointed out thatwithdrawal syndrome after the cessation of a chronically used drug often shows an exaggerated response which is normally suppressed by the drug which produced adependence. They suggested the model according to which a drug has bothexcitatory anddepressive effects. Depressive effects generatehypersensitivity, but at the same time they mask it. When drug usage stops, hypersensitivity becomes unmasked.[3]
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