Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types ofcollagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to theDictyostelium discoideum proteindiscoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). A closely related family member is theDDR2 protein.[6] In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian,esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to severalHLA class I genes.Alternative splicing of this gene results in multiple transcript variants.[5]
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