This gene encodes a member of thecytochrome P450 superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33.[4]
CYP4Z1 is overexpressed in breast cancer cells.[3] It has also been demonstrated that the expression of the CYP4Z1 gene is upregulated by activatedglucocorticoid andprogesterone receptors.[5] The overexpression of CYP4Z1 is associated with the breast cancer cells' increased production of20-Hydroxyeicosatetraenoic acid (20-HETE); it is hypothesized that CYP4Z1 metabolizesarachidonic acid to 20-HETE and that this overproduction is responsible for increasing the growth and spread of breast cancer cells in human breast cancer.[6][7] CPZ4Z1 is likewise overexpressed in ovarian cancer cells.[7] These studies also suggest that CYP4Z1 will be a valuable marker to distinguish between benign and malignant breast and ovarian growths in humans and/or the prognoses of malignant growths in these tissues.
^Savas U, Hsu MH, Griffin KJ, Bell DR, Johnson EF (April 2005). "Conditional regulation of the human CYP4X1 and CYP4Z1 genes".Arch. Biochem. Biophys.436 (2):377–85.doi:10.1016/j.abb.2005.02.022.PMID15797250.
^abZheng L, Li X, Gu Y, Lv X, Xi T (Feb 2015). "The 3'UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1".Breast Cancer Research and Treatment.150 (1):105–18.doi:10.1007/s10549-015-3298-2.PMID25701119.S2CID11952881.
Zöllner A, Dragan CA, Pistorius D, Müller R, Bode HB, Peters FT, Maurer HH, Bureik M (Apr 2009). "Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid".Biological Chemistry.390 (4):313–7.doi:10.1515/BC.2009.030.PMID19090726.S2CID13454640.
Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (Jan 2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants".Pharmacogenetics.14 (1):1–18.doi:10.1097/00008571-200401000-00001.PMID15128046.
This article incorporatespublic domain material from"Entrez Gene: CYP4Z1".Reference Sequence collection.National Center for Biotechnology Information.
