CYP2A7 (cytochromeP450, family2, subfamilyA, polypeptide7) is aprotein that in humans is encoded by theCYP2A7gene.[4][5]
This gene encodes a member of thecytochrome P450 superfamily ofenzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drug metabolism and synthesis ofcholesterol,steroids and otherlipids. This protein localizes to theendoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.[6]
^Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (January 2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants".Pharmacogenetics.14 (1):1–18.doi:10.1097/00008571-200401000-00001.PMID15128046.
Wang HH, Liao YW, Chiang HL, et al. (2009). "Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population".Pharmacogenomics.10 (3):359–74.doi:10.2217/14622416.10.3.359.PMID19290787.
Fernandez-Salguero P, Gonzalez FJ (1995). "The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis".Pharmacogenetics.5 (Special Issue): S123–8.doi:10.1097/00008571-199512001-00013.PMID7581481.
Cauffiez C, Lo-Guidice JM, Quaranta S, et al. (2004). "Genetic polymorphism of the human cytochrome CYP2A13 in a French population: implication in lung cancer susceptibility".Biochem. Biophys. Res. Commun.317 (2):662–9.Bibcode:2004BBRC..317..662C.doi:10.1016/j.bbrc.2004.03.092.PMID15063809.
Smith G, Stubbins MJ, Harries LW, Wolf CR (1998). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily".Xenobiotica.28 (12):1129–65.doi:10.1080/004982598238868.PMID9890157.
He XY, Shen J, Ding X, et al. (2004). "Identification of critical amino acid residues of human CYP2A13 for the metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen".Drug Metab. Dispos.32 (12):1516–21.doi:10.1124/dmd.104.001370.PMID15333516.S2CID26225467.
Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants".Pharmacogenetics.14 (1):1–18.doi:10.1097/00008571-200401000-00001.PMID15128046.
He XY, Shen J, Hu WY, et al. (2004). "Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation".Arch. Biochem. Biophys.427 (2):143–53.doi:10.1016/j.abb.2004.03.016.PMID15196988.
Herr D, Bettendorf H, Denschlag D, et al. (2006). "Cytochrome P2A13 and P1A1 gene polymorphisms are associated with the occurrence of uterine leiomyoma".Arch. Gynecol. Obstet.274 (6):367–71.doi:10.1007/s00404-006-0201-8.PMID16835796.S2CID28342598.
Song DK, Xing DL, Zhang LR, et al. (2009). "Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China".Cancer Detect. Prev.32 (5–6):416–23.doi:10.1016/j.cdp.2009.02.003.PMID19303722.
Wang H, Tan W, Hao B, et al. (2003). "Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK".Cancer Res.63 (22):8057–61.PMID14633739.
Cheng XY, Chen GL, Zhang WX, et al. (2004). "Arg257Cys polymorphism of CYP2A13 in a Chinese population".Clin. Chim. Acta.343 (1–2):213–6.doi:10.1016/j.cccn.2004.01.017.PMID15115698.
Cauffiez C, Pottier N, Tournel G, et al. (2005). "CYP2A13 genetic polymorphism in French Caucasian, Gabonese and Tunisian populations".Xenobiotica.35 (7):661–9.doi:10.1080/00498250500202171.PMID16316926.S2CID39901230.
This article incorporatespublic domain material from"Entrez Gene: CYP2A7".Reference Sequence collection.National Center for Biotechnology Information.
