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CSPG5

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From Wikipedia, the free encyclopedia

Protein-coding gene in humans

CSPG5

Identifiers

Aliases

CSPG5, NGC, chondroitin sulfate proteoglycan 5

External IDs

OMIM:606775;MGI:1352747;HomoloGene:4795;GeneCards:CSPG5;OMA:CSPG5 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3p21.31	Start	47,562,238bp^[1]
Band	3p21.31	End	47,580,792bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 F2	Start	110,072,851bp^[2]
Band	9\|9 F2	End	110,091,644bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

endothelial cell

retinal pigment epithelium

frontal pole

Brodmann area 23

Epithelium of choroid plexus

Brodmann area 10

Region I of hippocampus proper

orbitofrontal cortex

entorhinal cortex

Brodmann area 46

Top expressed in

visual cortex

primary visual cortex

dentate gyrus of hippocampal formation granule cell

superior frontal gyrus

cingulate gyrus

prefrontal cortex

nucleus of stria terminalis

primary motor cortex

anterior amygdaloid area

piriform cortex

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding growth factor activity
Cellular component	integral component of membrane Golgi apparatus endoplasmic reticulum membrane membrane Golgi membrane plasma membrane integral component of plasma membrane extracellular region cell surface lysosomal lumen endoplasmic reticulum Golgi lumen Golgi-associated vesicle membrane glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane
Biological process	cell differentiation chondroitin sulfate biosynthetic process modulation of chemical synaptic transmission intracellular transport nervous system development multicellular organism development chondroitin sulfate catabolic process regulation of growth dermatan sulfate biosynthetic process regulation of signaling receptor activity trans-synaptic signaling, modulating synaptic transmission regulation of synaptic vesicle exocytosis cytoskeleton organization glial cell projection elongation positive regulation of substrate adhesion-dependent cell spreading signal transduction
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


10675


29873

Ensembl


ENSG00000114646


ENSMUSG00000032482

UniProt


O95196


Q71M36

RefSeq (mRNA)


NM_006574 NM_001206942 NM_001206943 NM_001206944 NM_001206945


NM_001166273 NM_013884

RefSeq (protein)


NP_001193871 NP_001193872 NP_001193873 NP_001193874 NP_006565


NP_001159745 NP_038912

Location (UCSC)

Chr 3: 47.56 – 47.58 Mb

Chr 9: 110.07 – 110.09 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Chondroitin sulfate proteoglycan 5 is aprotein that in humans is encoded by theCSPG5gene.^[5]^[6]

Interactions

[edit]

CSPG5 has been shown tointeract withGOPC.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000114646 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000032482 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Yasuda Y, Tokita Y, Aono S, Matsui F, Ono T, Sonta S, Watanabe E, Nakanishi Y, Oohira A (May 1999). "Cloning and chromosomal mapping of the human gene of neuroglycan C (NGC), a neural transmembrane chondroitin sulfate proteoglycan with an EGF module".Neurosci Res.32 (4):313–22.doi:10.1016/S0168-0102(98)00098-4.PMID 9950058.S2CID 39609929.
^"Entrez Gene: CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)".
^Hassel, Burkhard; Schreff Matthias; Stube Eva-Maria; Blaich Uta; Schumacher Stefan (Oct 2003)."CALEB/NGC interacts with the Golgi-associated protein PIST".J. Biol. Chem.278 (41). United States:40136–43.doi:10.1074/jbc.M305577200.ISSN 0021-9258.PMID 12885772.

External links

[edit]

HumanCSPG5 genome location andCSPG5 gene details page in theUCSC Genome Browser.

Protein,glycoconjugate:glycoproteins andglycopeptides

Mucoproteins

Mucin	CD43 CD164 MUC1 MUC2 MUC3A MUC3B MUC4 MUC5AC MUC5B MUC6 MUC7 MUC8 MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC20
Other	Haptoglobin Intrinsic factor Orosomucoid Peptidoglycan Phytohaemagglutinin Ovomucin

Proteoglycans

CS/DS	Decorin Biglycan Versican
HS/CS	Testican Perlecan
CS	Chondroitin sulfate proteoglycans:Aggrecan Neurocan Brevican CD44 CSPG4 CSPG5 Platelet factor 4 Structural maintenance of chromosomes 3
KS	Fibromodulin Lumican Keratocan
HS	Syndecan 1

Other

Growth factor receptor modulators

Angiopoietin

Agonists:Angiopoietin 1
Angiopoietin 4

Antagonists:Angiopoietin 2
Angiopoietin 3

Kinase inhibitors:Altiratinib
CE-245677
Rebastinib

Antibodies:Evinacumab (against angiopoietin 3)
Nesvacumab (against angiopoietin 2)

CNTF

EGF (ErbB)

EGF (ErbB1/HER1)	Agonists:Amphiregulin Betacellulin EGF (urogastrone) Epigen Epiregulin Heparin-binding EGF-like growth factor (HB-EGF) Murodermin Nepidermin Transforming growth factor alpha (TGFα) Kinase inhibitors:Afatinib Agerafenib Brigatinib Canertinib Dacomitinib Erlotinib Gefitinib Grandinin Icotinib Lapatinib Neratinib Osimertinib Vandetanib WHI-P 154 Antibodies:Cetuximab Depatuxizumab Depatuxizumab mafodotin Futuximab Imgatuzumab Matuzumab Necitumumab Nimotuzumab Panitumumab Zalutumumab
ErbB2/HER2	Agonists:Unknown/none Antibodies:Ertumaxomab Pertuzumab Trastuzumab Trastuzumab deruxtecan Trastuzumab duocarmazine Trastuzumab emtansine Kinase inhibitors:Afatinib Lapatinib Mubritinib Neratinib Tucatinib
ErbB3/HER3	Agonists:Neuregulins (heregulins) (1,2,6 (neuroglycan C)) Antibodies:Duligotumab Patritumab Seribantumab
ErbB4/HER4	Agonists:Betacellulin Epigen Heparin-binding EGF-like growth factor (HB-EGF) Neuregulins (heregulins) (1,2,3,4,5 (tomoregulin, TMEFF))

FGF

FGFR1	Agonists:Ersofermin FGF (1,2 (bFGF),3,4,5,6,8,10 (KGF2),20) Repifermin Selpercatinib Trafermin Velafermin
FGFR2	Agonists:Ersofermin FGF (1,2 (bFGF),3,4,5,6,7 (KGF),8,9,10 (KGF2),17,18,22) Palifermin Repifermin Selpercatinib Sprifermin Trafermin Antibodies:Aprutumab Aprutumab ixadotin Kinase inhibitors:Infigratinib
FGFR3	Agonists:Ersofermin FGF (1,2 (bFGF),4,8,9,18,23) Selpercatinib Sprifermin Trafermin Antibodies:Burosumab (against FGF23)
FGFR4	Agonists:Ersofermin FGF (1,2 (bFGF),4,6,8,9,19) Trafermin
Unsorted	Agonists:FGF15/19

HGF (c-Met)

Agonists:Fosgonimeton
Hepatocyte growth factor

Potentiators:Dihexa (PNB-0408)

IGF

IGF-1	Agonists:des(1-3)IGF-1 Insulin-like growth factor-1 (somatomedin C) IGF-1 LR3 Insulin-like growth factor-2 (somatomedin A) Insulin Mecasermin Mecasermin rinfabate Kinase inhibitors:BMS-754807 Linsitinib NVP-ADW742 NVP-AEW541 OSl-906 Antibodies:AVE-1642 Cixutumumab Dalotuzumab Figitumumab Ganitumab Robatumumab R1507 Teprotumumab Xentuzumab (against IGF-1 and IGF-2)
IGF-2	Agonists:Insulin-like growth factor-2 (somatomedin A) Antibodies:Dusigitumab Xentuzumab (against IGF-1 and IGF-2)
Others	Binding proteins:IGFBP (1,2,3,4,5,6,7) Cleavage products/derivatives with unknown target:Glypromate (GPE, (1-3)IGF-1) Trofinetide

LNGF (p75^NTR)

Antibodies:Against NGF:ABT-110 (PG110)
ASP-6294
Fasinumab
Frunevetmab
Fulranumab
MEDI-578
Ranevetmab
Tanezumab

Aptamers:Against NGF:RBM-004

Decoy receptors:LEVI-04 (p75^NTR-Fc)

PDGF

Agonists:Becaplermin
Platelet-derived growth factor (A,B,C,D)

RET (GFL)

GFRα1	Agonists:Glial cell line-derived neurotrophic factor (GDNF) Liatermin Kinase inhibitors:Vandetanib
GFRα2	Agonists:Neurturin (NRTN) Kinase inhibitors:Vandetanib
GFRα3	Agonists:Artemin (ARTN) Kinase inhibitors:Vandetanib
GFRα4	Agonists:Persephin (PSPN) Kinase inhibitors:Vandetanib
Unsorted	Kinase inhibitors:Agerafenib

SCF (c-Kit)

Agonists:Ancestim
Stem cell factor

TGFβ

Seehere instead.

Trk

TrkA	Agonists:Amitriptyline BNN-20 BNN-27 Cenegermin DHEA DHEA-S Gambogic amide NGF Tavilermide Antagonists:ALE-0540 Dexamethasone FX007 Testosterone Positive allosteric modulators:ACD856 ACD857 Ponazuril (ACD855) Toltrazuril Negative allosteric modulators:VM-902A Kinase inhibitors:Altiratinib AZD-6918 CE-245677 CH-7057288 DS-6051 Entrectinib GZ-389988 K252a Larotrectinib Lestaurtinib Milciclib ONO-4474 ONO-5390556 PLX-7486 Rebastinib SNA-120 (pegylated K252a)) Antibodies:Against TrkA:GBR-900;Against NGF:ABT-110 (PG110) ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers:Against NGF:RBM-004 Decoy receptors:ReN-1820 (TrkAd5)
TrkB	Agonists:3,7-DHF 3,7,8,2'-THF 4'-DMA-7,8-DHF 7,3'-DHF 7,8-DHF 7,8,2'-THF 7,8,3'-THF Amitriptyline Braegen-02 BDNF BNN-20 Deoxygedunin Diosmetin DMAQ-B1 HIOC LM22A-4 N-Acetylserotonin NT-3 NT-4 Norwogonin (5,7,8-THF) R7 R13 (BrAD-R13, Braegen-01) TDP6 Antagonists:ANA-12 Cyclotraxin B Gossypetin (3,5,7,8,3',4'-HHF) Ligands:DHEA Positive allosteric modulators:ACD856 ACD857 Ponazuril (ACD855) Toltrazuril Kinase inhibitors:Altiratinib AZD-6918 CE-245677 CH-7057288 DS-6051 Entrectinib GZ-389988 K252a Larotrectinib Lestaurtinib ONO-4474 ONO-5390556 PLX-7486
TrkC	Agonists:BNN-20 DHEA NT-3 Positive allosteric modulators:ACD856 Kinase inhibitors:Altiratinib AZD-6918 CE-245677 CH-7057288 DS-6051 Entrectinib GZ-389988 K252a Larotrectinib Lestaurtinib ONO-4474 ONO-5390556 PLX-7486