ATP2A2 also known assarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) is anATPase associated withDarier's disease[1] andAcrokeratosis verruciformis.
| ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ATP2A2 | ||||||
| Alt. symbols | ATP2B, DAR | ||||||
| NCBI gene | 488 | ||||||
| HGNC | 812 | ||||||
| OMIM | 108740 | ||||||
| RefSeq | NM_001681 | ||||||
| UniProt | P16615 | ||||||
| Other data | |||||||
| EC number | 3.6.3.8 | ||||||
| Locus | Chr. 12q23-q24 | ||||||
| |||||||
This gene encodes one of theSERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic orendoplasmic reticula of muscle cells.[2] This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms.
References
edit- ^Ren YQ, Gao M, Liang YH, Hou YX, Wang PG, Sun LD, Xu SX, Li W, Du WH, Zhou FS, Shen YJ, Yang S, Zhang XJ (July 2006). "Five mutations of ATP2A2 gene in Chinese patients with Darier's disease and a literature review of 86 cases reported in China".Archives of Dermatological Research.298 (2):58–63.doi:10.1007/s00403-006-0658-0.PMID 16552539.S2CID 31728235.
- ^Entrez Gene: ATP2A2. ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
External links
edit- ATP2A2+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)
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